Vetdrugs 2.0Progesterone is the natural luteal steroid hormone essential to regulation of the estrous cycle and support of pregnancy. Veterinary preparations provide controlled progestational exposure in reproductive-management protocols. A principal application is synchronization of estrus or ovulation in cattle, including selected noncycling animals, using an appropriate sustained-release product.
Group
Progestogen hormone
Mechanism of Action
Progesterone activates intracellular progesterone receptors and produces luteal-phase feedback on hypothalamic and pituitary signaling. Suppression of the preovulatory gonadotropin surge temporarily prevents ovulation during exposure. Withdrawal produces a fall in progesterone, allowing coordinated follicular maturation and estrus when the animal and accompanying protocol are responsive. Receptor effects also support progesterone-dependent reproductive tissues.
Indications
- Synchronization of estrus or ovulation in cycling cattle within a supported breeding protocol.
- Induction of estrous cycles in selected anestrous lactating dairy or beef cows using an indicated progesterone device and associated reproductive protocol.
- Selected resynchronization of return to estrus after insemination with a product-supported protocol.
Contraindications
- Do not use a vaginal device in animals with an unsuitable genital tract or outside its labelled reproductive population.
Interactions
- GnRH and prostaglandins may be required at specified times; a device is not a complete timed-AI protocol by itself.
Adverse effects
- Transient vaginal mucus/discharge or irritation; device loss may occur.
Toxicity
Remove a retained or incorrectly used device and reassess clinically; absorbed exposure cannot be calculated from the total device content.
Monitoring and Administration
For Eazi-Breed CIDR cattle insert, use one intravaginal device in the complete selected synchronization protocol; total progesterone content is 1.38 g, not an injected or daily systemic dose.
Use gloves and an appropriate applicator; clean and disinfect equipment between animals. Leave the removal tail accessible and remove at the specified time.
Single-use inserts reduce transmission risk; do not infer reuse or substitute sheep and cattle device sizes.
Oestrous-cycle synchronization: Intravaginal device, not external topical application: one cattle CIDR containing 1.38 g progesterone. A commonly labelled course is seven days, with accompanying hormone timing defined by the selected protocol. No daily mass dose is inferred.