Vetdrugs 2.0Bromhexine is a mucoregulatory and expectorant drug used as an adjunct in respiratory disease with tenacious secretions. Veterinary formulations support mucus clearance in selected livestock, poultry or companion-animal disorders. Its clinical purpose is improvement of secretion handling and bronchial drainage while treatment addresses the cause of the respiratory disease.
Group
Mucolytic
Mechanism of Action
Bromhexine modifies respiratory gland secretion and the glycoprotein network responsible for mucus viscosity and elasticity. Increased serous secretion and reduced cohesiveness of thick mucus facilitate its mobilization. Effects on mucociliary transport further support bronchial clearance. These actions improve removal of retained secretions through ciliary movement and productive coughing.
Dose Rates
Dogs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 1 mg/kg | PO | Every 12 h | Up to 5 days; Per-dose amount from total daily 2 mg/kg divided twice daily; not 2 mg/kg per dose. |
Cats
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 1 mg/kg | PO | Every 24 h | Up to 7 days |
Cattle
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 0.5 mg/kg | PO | Every 24 h | Up to 5 days; Do not use in: Cows producing milk for human consumption |
Pigs
| Use / stage | Dose | Route | Schedule | Instructions |
|---|---|---|---|---|
| Respiratory mucus adjunct | 0.2–0.5 mg/kg | PO | Every 24 h | Up to 5 days |
Indications
- Adjunctive treatment of respiratory disease with excessive or tenacious mucus in calves, pigs or poultry using an indicated product.
- Adjunctive improvement of secretion clearance in selected canine, feline or equine tracheobronchial disease, with species- and formulation-specific clinical support.
Contraindications
- Hypersensitivity; the cited powder excludes cows producing milk for human consumption.
Interactions
- May increase oxytetracycline concentrations in bronchial mucus; clinical benefit of this interaction is uncertain.
Adverse effects
- Adverse reactions are not well characterised in the cited veterinary information; hypersensitivity remains possible.
Toxicity
Specific veterinary overdose information is limited; provide supportive care and assess the underlying respiratory disease.
Preparations
| Preparation | Form | Strength | Route |
|---|---|---|---|
| Bisolvon oral powder 10 mg/g Klocke Pharma-Service GmbH 10 mg bromhexine hydrochloride per g powder; dog dose is divided from the total daily amount. | Powder | 10 mg / g | PO |
Monitoring and Administration
Add powder to feed or drinking water immediately before administration; discard uneaten medicated feed or water after 24 hours.
Bisolvon dog label states 2 mg/kg TOTAL DAILY, divided twice daily; each dose is 1 mg/kg. This is also confirmed by its per-treatment powder table.
Store dry below 25°C; reseal opened sachets and discard unused contents within seven days. Cattle meat withdrawal two days and pig meat zero days for the cited powder.