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Acetylcysteine / Mucinac / Mucyst (Antidote for paracetamol)

ACETYLCYSTEINE

Category
  • Mucolytic expectorant
  • Antidote for paracetamol toxicity
Action

Sulfhydryl group of acetylcysteine breaks the disulfide bond in glycoproteins in exudates 

Enhance availability of endogenous glutathione thereby detoxify paracetamol

Reduce both purulent and non purulent secretions

Indication
  • Paracetamol toxicity
  • Respiratory disease
  • Thick mucus secretion
Dose

In paracetamol toxicity-

  • Initial dose @ 150 mg/kg PO / IV as 5% solution
  • Loading dose @ 70 mg/kg PO every 6 hrs (6-7 treatment)
Contraindications

Hepatic encephalopathy

Adverse Effects
  • Hypersensitivity in asthma patient
  • Nausea
  • Vomiting
  • Rarely Urticaria
Availability

Inj Mucyst (NEON)

  • 2m and 5ml ampoule
  • Each ml contain 200 mg

Tab Mucinac (CIPLA)

  • 600 mg
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