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Phenobarbitone / Gardinal

PHENOBARBITONE

Category

Antiseizure drug, Gen. Anaesthesia

Action

Antiepileptic effect by prolonging the GABA gated Cl channel opening and inhibition of amp receptors , inhibit the release of excitatory neurotransmitter glutamate, leading to reduced neuronal excitability

Indication

Initial medication of choice for the management of epileptic seizures

Dose

Dog-1-2. 5mg/kg body wt. Emergency management-Loading dose- 15-24mg/kg followed by maintenance dose of 2-3mg/kg

Cat-1. 5-3 mg/kg B. Wt. 

Birds-3. 5-7mg/kg B. Wt

Horse- 10mg/kg body wt. 

Ruminant- 10mg/ kg B.wt.

 

Contraindications

Not used in pregnant or lactating animals, diarrhoea, hepatic impairment, hypoglycemia

Adverse Effects

Headache, nausea, dizziness, vomiting, polydypsia, polyphagia, polyuria. 

In toy breeds, whinning is seen

Availability

Gardenal- 30mg, 60 mg tablet, Gardenal Syrup 20 mg/5mL

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