Chelating class of drug
Category'B' drug
Bind with available ca2+ and prevent further toxic effects of toxin
Bind with ca2+ so prevent the coagulation of blood
Used in reaction of heavy metal toxicity like Pb, Zn
Used in cosmic and food industries and with in scientific laboratories
Lead poisoning- (20ug/dL-70ug/dL) - 1000mg/M2 daily given IV or I'M
If lead poisoning > 70ug/dL
EDTA is combined with dimer caprol i. e. EDTA is administrated before dimercaprol
Adult with Nephropathy :- 500mg/M2 for every 24 hours for 5 days
Pediatric dosing:- chelation therapy is necessary in patients with blood lead levels over 45 mg/dL. If lead poisoning- 45 ug/dL to 70 ug/dL =>25 mg/kg/day for 5 days
If lead poisoning > 70 ug/dL=> IV administration of EDTA at 50 mg/kg/day in 6 doses
In children with cerebral edema
=> IV is avoided due to increase in intracranial pressure so we can go for I/M in that patients
•Renal toxicity
• Weight loss due to Zn deficiency
•Nausea
• Vomiting, chills, fatigue tremors, anemia
• Use of Na EDTA can cause severe hypocalcemai
Na+ EDTA, ca+ EDTA
Livodate Ca 20 (200mg/ml)