Direct acting Arterial and venous dialators

Nitroprusside metabolised into nitric oxide

Nitric oxide stimulate cGMP pathway producing relaxation of vascular muscles

• Hypertension
• Acute heart failure secondary to mitral regurgitation
• Refractory CHF
• In DCM with dopamine/dobulamine

Small animals: 1-5 mcg/kg/min  IV (Maximum 10mcg/kg/min) 

Patients with

• Compensatory hypertension
• Hepatic insufficiency
• Renal impairment
• Geriatric patients

• Rapid hypertension
• Irritant at infusion site
• Chronic use leads to thiocynate and cyanide toxicity

Prusid-5ml (50mg/5ml)