Non selective COX inhibitors

Inhibition of cyclo-oxygenase activity

Analgesia

Antipyrexia

Antithrombotic

Antiinflammatory

Dog and cat 25-40mg/kg PO 3 time daily for dog, once daily for cat 

Cardiac, Renal, Hepatic diseases and hypersensitivity 

Intestinal irritation

Anorexia

Nausea

DOTCHROME-DS

Sodium salicylate 200mg/ml

Coagulants

Transform fibrinogen into fibrin by gradually splitting off fibrinopeptide A, giving rise to der-A-fibrin monomers, which polymerize end to end to fibrin

Control bleeding in surgical, dental and gynaecological cases 

Dog and cats- 10mg/kg

Cattle- 10-15 mg/kg

Hypersensitive patients

Not use in venous or arterial thrombosis 

Injection Blood off 20ml

Tablet Blood off 500mg

Inj Botropase - 1ml

Sol Botroclot - 10 ml

Sol Botroclot forte - 10 ml

Cardiac glycoside 

• Increase intracellular Calcium ion
• Increase contractility of myometrium

• Arterial tachycardia
• CHF

Dog= 5-8mcg/kg

Digitalis toxicity in overdose

• Diarrhoea
• Dizziness
• Blurred vision
• Skin rashes

• Injection Digoxin 0.5mg/2ml
• Tab. Digox 0.25mg

Anticholinergic and pre anaesthetic

Competitive antagonist of acetylcholine at all muscarinic receptor site

Pre anaesthetic
Antispasmodic
Broncodilator
Cardiac stimulant
Antidote to anticholinesterase
Sinus bradycardia
Cardiac arrhythmia
Brady arrhythmia
Organophosphate poisoning
Carbamate poisoning
Opthalmic ointment

PRE ANAESTHETIC

Cat and dog @ 0.02-0.1 mg/kg IM/SC

Cattle and horse @ 0.02-0.06 mg/kg IM/SC

ANTI CHOLINESTERASE

Cat and dog @ 0.2-2 mg/kg (1/4 IV and 3/4 IM/SC then same or half dose at 3-4 hours interval IM/SC )

Cattle, Horse, Sheep and goats @ 0.2-0.5 mg/kg (1/4 IV and 3/4 IM/SC then same or half dose at 3-4 hours interval IM/SC )

For adjunctive treatment of BRADYCARDIA

Cat & dog @ 0.02-0.04 mg/kg IM/SC/IV
@ 0.04 mg/kg PO 3-4 times daily

For opthalmic use 

0.5-2% opthalmic solution
1 drop, 2-3 times daily until get pupillary dilatation

Glaucoma
CHF
Myocardial ischemia
Intestinal hypomotility
Tachycardia
Obstructive uropathy
Hepatic or renal disease
GI infection

Dry mouth
Dysphagia
Constipation
Increased thirst
mydriasis
Tachycardia
Tachypnoea restlessness urine retention

Inj Tropin 1ml
Inj Atrotas 1ml

Bronchodilators 

Inhibition of phosphodiesterase enzyme leading to accumulation of cAMP

Bronchodilators 

Cat - 4mg/kg BID

Induce excite and hypocalcemia

Induce excite and hypocalcemia

Deryphilline - Tab 100 mg and Inj 220mg/2ml

• Bronchodilators
• Beta agonist

• Selective action on beta-2 adrenergic receptors - stimulate receptors to relax bronchial smooth muscles
• Inhibit release of inflammatory mediators especially from mast cells
• Direct acting Sympathomimetic

• Relieve Bronchospasm
• Relieve Bronchoconstriction

DOG@100-300 mcg/kg BW TID

Cat@100 mcg/kg BW TID/QID

Horse@0.008 mg/kg PO two times daily

Cardiac disease and late pregnancy, abolish uterine contraction.

Tachycardia

Nervousness

CNS excitation

Muscle Tremors

Tab. ASTHALIN 2mg, 4mg

Syrup. ASTHALIN 100ml (2mg/5ml)

Tab. LEVOLIN 1mg, 2mg

Tab. SALBID 2mg, 4mg

Bronchodilator

Inhibition of Phosphodiesterase enzyme

Treat coughs caused by bronchospasm (Or) Bronchoconstriction

Cat - 4 mg/kg BID

Hypocalcemia

Persistent  vomiting, increase in urine volume

DERIPHYLLIN Theophylline 50.6mg +etophylline 169.4 mg/2ml

DERIPHYLLIN Tab 100 mg (etophylline 77 mg+ Theophylline 23 mg) 

Bronchodilator

Act on Beta2 adreno receptor affecting Bronchoconstriction

Treat bronchial asthma in cats

Dog - 0.05-0.1 mg/kg bwt TID PO

Horse - 0.0033 mg/kg bwt  IV                     0.025 mg/kg bwt PO

In pregnancy and lactation

Produce tremors, increased heart rate, dizziness and excitement

Tab bricanyl 2.5mg and 5mg

Syrup ascoril 200ml

Bronchodilator

• H1 receptor antagonist
• Antimuscarinic effect on vestibular apparatus 

• Allergy
• Rashes
• Pruritis 
• Anxiolytic
• Antiemetic 

Ruminant=0.5-1mg/kg q 6-8hrs I/M or I/V

Dog and cat= 1-2mg/kg PO

• Hypertension
• Hepatic disorder
• Increase intraocular pressure
• Pregnancy

• Dry mouth
• Dizziness
• Nausea
• Increase chest congestion

• Tab. Benadryl AH 25mg capsule
• Tab. Hydramin 25mg capsule
• V Cofex Syrup 500ml, 1L and 5L

Bronchodilator

Inhibition of phosphodiesterase (PPE 1 & PPE 2)enzymes

• CHF
• Bronchitis
• Emphysema
• COPD

• Dog=6-10mg/kg I/V or PO
• Cat=4-6mg/kg I/V or PO

• Pregnancy hypocalcaemia
• Hepatic disorder

• Nausea
• Vomiting
• Headache

Deriphyllin  - 2ml