Ectoparasiticides

Inhibit glutamate gated channel results

Flaccid paralysis of parasite

Flea and ear mite infestations

Dog @ 6mg/kg

Cat @ 6mg/kg

Not use under 6 week of age

Swelling and pruritus after administration due to hypersensitivity of dead parasites

Redicate spoton 0.5ml, 0.7ml, 1ml, 2ml, 3ml

Revolution

Anti helmintics drug

Uncoupling of oxidative phosphorylation in flukes and distrubs the production of ATP in flukes. 

Amphistomiasis, moneziasis, fascioliosis(fasciola hepatica) 

• Cattle/Buffalo- 10-15mg/kg  PO
• Sheep/goat- 15 mg/kg  PO

It's not used in cat and dog. 

Salivation, fever, cutaneous vasodilation, tachycardia, severe respiratory distress. 

Distodin 

• Bolus
• 1g, 200mg Oxyclozanide

 Clozan plus

• Tablet
• 1.5g ( Oxyclozanide+Levamisole) 

Zanil

• Susp. 100ml
• Each ml contains 34 mg

Neozide

• Solution 90 ml, 1 L (Oxyclonazide + Levamisole)

Neozide plus

• Bolus 1.5g (Oxyclonazide + Levamisole) 
• Solution 90 ml (Oxyclonazide + Levamisole) 

Oxyleva

• Liquid 90ml( oxyclonazide + levamisole) 

Hexanide

• Bolus 1g (Oxyclonazide)

Hexanide Plus

• Supension 90 ml, 1 L (Oxyclonazide + Levamisole)

Fasnil/Fasmin

• Bolus 1.5 g, 6 g (Oxyclonazide + Levamisole)

Amphicide

• 1.5 g (Oxyclonazide + Levamisole)

Anthelmintics

Affect cl(-) ion channel of the nervous system of arthropods and nematodes.

It increases the membrane permeability. It causes hyperpolarization and death.

Enhances the release of GABA at presynaptic neuron.

Heart worm, ancylostoma spp,Toxacara, Toxascaris,Tricheris,Demodex, strangles vulgaris,Ascarids,pinworm,Hairworms,Stomach worms,lungworms, mites,lice.

Cattle-0.2mg per kg.

Horse-0.4mg per kg.

Cat-1 mg/kg.

Dog

Heart worms-3 mcg per kg ( every 30days) PO

Mange - 0.2 to 0.25 mg/kg(3 to 6 weeks).

Demodicosis-0.2 to 0.4 mg/kg -PO.

Dog< 2 month age.

Inj moxidecton (INTAS)

• 10 ml vials
• each ml contains 10 mg moxidectin + 40 mg benzyl alcohol 

Proheart 12 (10mg/ ml) 10 ml vial.

Anti helmintics

Inhibit polymerization of tubulin in parasi to and blocks the glucose uptake

Trematodal infections, especially fasciola species

Cattle, Buffalo -12 mg/kg

Sheep, goat - 10 mg/kg

Hypersensitivity

Skin irritation

Suspension triclamar (VIRBAC)

• 100ml and 500ml bottle 
• each 5ml contains 250 mg triclabendazole + 5mg ivermectin 

Olgardsolution 250 ml, 500ml, 1L                                    TRICLASOLE, FASINE           BOLUS- 900mg                        suspension - 100ml, 500ml, 1 litre  (50mg/ml) 

Endo-ectoparasiticide 

Enhance release of GABA at presynaptic neurons resulting in paralysis of parasites and death

• Nematode, lice, mite, tick infestations
• Preventive for heart warm in dogs

• Ectoparasite: 0.2-3 mg/kg SC   PO
• Endoparasite: 0.2-0.4 mg/kg  SC  PO weekly
• Demodex: 0.6 mg/kg SC   PO daily

• Foals less than 4 months old, puppies less than 6 weeks old
• Collie type breeds and shelties, Australian Shepherds

• Hypersensitivity reactions
• Neurotoxicity
• Induce serious effects by killing the larva when they are in vital areas

Inj. Neomec (INTAS)

• 1 ml, 10ml and 100ml vials
•  Each ml contains 10 mg

Inj. Neomec sx (INTAS)

• 10ml vials
•  Each ml contains 10 mg ivermectin + 100 mg clorsulon

Inj. Neomec LA (INTAS)

• 10ml vials
•  Each ml contains 31.5 mg ivermectin + 0.18% w/v methyl paraben + 0.02% w/v propyl paraben

Inj Endact LA (VETOQUINOL)

• 10 ml vials
• 31.5mg/ml
• S/C route
• 1ml for 50 kg bwt

Inj Endact Plus (VETOQUINOL)

• 10 ml vials
• Ivermectin 1%w/v + clorsulon 10%w/v per ml
• S/C route
• 1ml for 50 kg bwt

Inj hitek (VIRBAC) 

• 10ml, 30ml and 100ml vials
• Each ml contains 10 mg

Inj hitek F (VIRBAC) 

• 10ml vials
• Each ml contains 10 mg ivermectin + 100 mg clorsulon

Inj hitek platinum (VIRBAC) 

• 10ml vials
• Each ml contains 31.5 mg

Solution hitek (VIRBAC) 

• 100ml, 500ml, 1L and 2 L bottle 
• Each ml contains 0.8 mg

Tab hitek (VIRBAC) - 80 mg

bolus fendikind plus (VET MANKIND) - (3 gm fenbendazole + 100 mg ivermectin/ bolus)

Inj

• Mectin- 1 ml, 7ml, 10 ml, 20 ml -- (10mg/ml) 
• Avertin, endicitin

Oral solutions

• Neomec- 100ml, 500ml, 1L -- (0.08% W/V) 
• Hitek- 100ml, 500ml, 1L -- (0.08% W/V) 
• Iverix, endicitin (0.1%W/V), (0.8%) 

Tablet

• Neomec 10mg
• I-meet 20mg
• Ivertin 10mg

Bol

• Hitek 80mg

Pouron

• Hitek 50 ml (0.5% W/V)

Powder

• Hitek 100g, 200g, 1kg (1% W/V) 

Anhelmintic

Depolarization neuromuscular blocking agents,

In Hemonchus spp - Inhits fumarate reductase.

Hemonchus spp, Ostertagia spp, Trichostrongylus spp,Nematodirus spp, ,cooperia spp, Oesophagestomum radiatum.

Cattle- 9.68 mg / kg PO

Sheep and goat - 10 mg / kg -PO.

Nil

NA

Oral solution banminth 100ml

Bolus banminth 594mg

Tab banminth 118.8mg

Antihelminthic drug

Cesticide action, increases the cell membrane permeability of worms resulting in loss of intracellular Ca+ and causes paralysis thus the parasites are phagocytised and digested

Treatment of pipylidiam caminum / taenia, ecchinacea, used in pets travel scheme to UK

Dogs- 5.0 mg/kg PO 5 mg/ kg spot on, 

Cats - 5 mg/ kg b. Wt

Elephant- 2.5-4 mg/ kg 

Do not use in young puppies/ kitten as they are susceptible to tapeworms, don't use spot on for animals having 1 kg body wt. 

Injection may cause localized sensitivity to tissue especially in cats, can cause transient hypersalivation if cat lick area where spoton applied, oral administration may cause anorexia, vomition, lethargy and diarrhoea

Drontal plus from 2 weeks of age, Drontal cat tab. From 6 week age, spoton

Antihelminthic drug

Tetrahydropyrimidine inhibitor of acetyl choline

Against nematode

Dog - 5-10 mg/kg repeat  after  1 week (ancyclostoma species) 

Cat- 20-30 mg/kg repeat after 1 week

Cattle-6. 5-13mg/kg B. Wt

Renal problems, epilepsy, hepatic disorders

Nausea, diarrhoea, vomiting, stomach cramps

Tab Kiwoff cat, worm trap, nemocid

Tab prazisam plus (VETOQUINOL) - 30 x 2 tablets (each tablets contains praziquantel 50mg + pyrantel paomate 144mg + fenbendazole 500mg)

Suspension Worex

Syrup Nemocid

• 10 ml
• Each ml contains 50 mg

Anthelmintics

Inhibitors of ACh asterase

Nematodes and microfilaricidal

Cat and dog@ 7.5mg/kg for microfilaria and 2.5mg/kg as immunomodulant

Cattle @ 5.5-11mg PO

Sheep & goat @ 8mg/kg

Rabbit @ 12.5-20mg/kg PO

Hyper sensitivity patients

High dose cause immuno depressant

Bolus nilzan (VIRBAC) - 2 bolus per cattle/buffalo

suspension nilzan (VIRBAC) - 100ml and 500ml and 1000ml bottle 

Powder nilverm (VIRBAC) 10gm and 100 gm

Inj levamisole 2ml, 5ml (15mg/ml)

Tab decaf is 150mg

Bolus amphicide 1.5gm

Liq nilzan 100ml, 150ml, 500ml

Syrup hexanide plus 90ml, 1L

Solution neozide plus 90ml, 500ml

Pro benzimidazole (anti helmintics) 

Blocking the microtubules, perturbs the uptake of glucose, which eventually empties the glycogen reserves, so whole energy metabolism blocked worms that are paralyzed and die or are expelled

roundworms, hookworm, whipworm in puppies

Dogs- orally 10-25 mg/kg/day

Cats- orally 10mg/kg

Cattle- orally 7.5-10mg/kg

Pregnant animal

In pregnant animals

Tab skyworm

Tab sky worm XL

Tab canworm

Tab Kiwof plus

Susp kiwof 

Tab endogard for canine

Tab cazitel plus for canine