Antifungal

Keratolytic action

Desquamation of Stratum corneum

Keratolytic

Dandruff

Treatment for Acne, Seborrhoea, Psoriasis, Calluses, Warts

Cattle, Sheep, Goat, Horse, Poultry @ 2-400mcg/kg BW/day

Avoid contact with eyes and mucous membrane

Skin Irritation

Increase amount of moisture in the skin, Itching, Peeling of skin, Difficult breathing

CL Ear cleanser 50ml, 100ml

Ectofree dog wash 200ml

Epiotic Ear cleaner 50ml, 100ml

Imidazole antifungal 

Topical 

Alters fungal cell wall permeability by inhibition of ergosterol synthesis.

Dermatophycoses

NA

NA

NA

Canesten - Cream 15 gm and Solution 15gm

Imidil - Powder 30gm, cream 15gm, Solution 15ml

Antifungal

Inhibitions of synthesis of ergosterol in fungal cell membrane

1. Systemic mycosis, superficial candidiasis fungal, urinary tract infections

Dog- 2.5-5 mg/kg p/o q 12 hrs

Cat-50mg/cat 1 IV (occulat) 

Urinary candidiasis- 5-10 mg/kg

Pregnant animal

In hypersensitive animals 

Cap fumycin (150mg) 

Eyedrops flucomet 5 ml

Capsule forcan 50mg, 150mg, 200mg

Antifungal

• Fungistatic
• Alter the cellular membrane of fungi increasing membrane permeability allowing leakage of cellular contents and impaired uptake of purine, pyrimidine precursors

• Aspergillosis
• Cryptococal meningitis
• Blastomycosis and histoplasmosis
• Candidiasis or dermatophytosis
• Sporotrichosis
• Coccidioldes Immitis osteomyelitis

• Horse: 3-5 mg/kg   12-24 ht  PO
• Dog: 2.5 mg/kg PO  12 hrs or 5 mg/kg  24 hrs PO            Dermatophytes: 3mg/kg/day  PO for 15 days                 Malssezia: 5mg/kg/day 24hrs PO
• Cat: 1.5-3mg/kg upto 5mg/kg PO

Pregnant animals

Not used in hepatic impairments

• Caps. Canditral 100 mg
• Caps. Vetconazole 100mg, 200mg
• Caps. Itaspor 100mg
• Caps. Itrapet 100mg
• Caps. Sporanox 100mg
• Oral solution Itrapet 100mg/ml - 52 ml

Antifungal medication  (Imidozol) 

• Ketoconazole prevent the synthesis of ergosterol (the fungal equivalent of cholesterol) thereby increasing membrane fluidity and preventing growth of the fungus. 

• Skin infection
• Fungal ear infection
• Cryptococcosis
• Coccidioidomycosis ( valley fever)
• Blastomycosis

Dog @ 5mg/kg  BD / PO

Cat @ 5mg/kg   BD / PO

• Teratogenic and embryotoxic. 
• Hepatotoxic

• Inappetence
• Vomiting
• Pruritus
• Alopecia and reversible lightening of coat. 

Tab. Care best

• 200 mg

Tab. K-pet

• 200mg

Tab Petoral K 

• 200 mg

Tab. Ketohat-DT

• 200 mg

Shampoo Care best

• 100 ml, 200 ml

Shampoo Conaseb

• 100 ml

Shampoo Ketochlor (VIRBAC)

• • 200 ml

Shampoo Tritix

• 200 ml

Spray Dermotil-k 

• 100 ml

Ketosor cream

• 2%w/w
• 30 gm

Ketovate cream

• 20 gm

Ketovate lotion

• 100 ml

Antifungal

Arresting the metaphase of cell division by disrupting the mitotic spindle

Dermatophytic fungal injections of skin, hair, claws, Treat ringworm(T.equaneum, M. gypseum) in horses

Dogs/cats- microsized 10-30(upto 130) mg /Kg per day 

Horses and Cattle-5-10 mg/kg per day for 3-6 weeks or longer

Swine- dermatophytic 20mg/kg po once daily for 6 weeks

Patients with hepatocellular failure, Pregnancy

Hepatotoxic, Vomiting, Diarrhoea, CNS signs, Hemolytic alterations, cleft palate in cats

Grisovin FP tab 250 mg, GriflunvinV, Pulvicin P/G, Pulvicin U/F

Anti fungal

It cause pore formation in fungal cell wall that leads to leakage of K+, Na+, H+ and Cl- and cause fungal death 

Systemic fungal infection

leshmaniasis

Cats @ 0.1-0.25 mg/kg IV every 48 hours

dogs @ 0.2605-1mg/kg IV every 48 hours

Horses @ 0.3-0.6mg/kg IV  slow dilute 24-48 hours

Severe lever dysfunction

Nephrotoxicity

Amphocil

Ambisome

Fungizone 

Abelcet

Antiseizure drug, Gen. Anaesthesia

Antiepileptic effect by prolonging the GABA gated Cl channel opening and inhibition of amp receptors , inhibit the release of excitatory neurotransmitter glutamate, leading to reduced neuronal excitability

Initial medication of choice for the management of epileptic seizures

Dog-1-2. 5mg/kg body wt. Emergency management-Loading dose- 15-24mg/kg followed by maintenance dose of 2-3mg/kg

Cat-1. 5-3 mg/kg B. Wt. 

Birds-3. 5-7mg/kg B. Wt

Horse- 10mg/kg body wt. 

Ruminant- 10mg/ kg B.wt.

Not used in pregnant or lactating animals, diarrhoea, hepatic impairment, hypoglycemia

Headache, nausea, dizziness, vomiting, polydypsia, polyphagia, polyuria. 

In toy breeds, whinning is seen

Gardenal- 30mg, 60 mg tablet, Gardenal Syrup 20 mg/5mL

Antiemetics

Centrally acting suppresses dopamine activity in CNS to produce sedation 

Sedation, tranquility, antiemetic

Dog/cat-0.1-0.5mg/kg q 5-6 h, S/C or 0.25-0.35mg/kg q 6-8h P/O

Sedation, vasodilation, hypotension, receptor blocking property

Muscle stiffness uncontrollable movement

Stemetil

• Tab 5 mg
• 1 ml Ampoule
• Each ml contains 12.5 mg

Phenothiazine derivative

Blockade of a-adrenoreceptors

Central sedative effects

Preanaesthetic 

Immobilize the aggressive animals

Cat & Dog @ 1-2 mg/kg IV or IM and 3mg/kg orally

Cattle @ 1 mg/kg IM

Goat and sheep @ 2 mg/kg IM

In horses, it cause drowsiness and depression.

Adrenaline should not be administered.

Avoided in debility animals and OP poisoning cases.

Chlorpromazine

Tab 10mg, 25mg, 50mg, 100mg nag Inj 2ml (2.5%)

Megatil

Tab 25mg, 50mg, 100mg, 200mg and Inj 2ml (50mg/2ml)