Antiprotozoal drug (Coccidiosis)
Vitamin B1 or structural analogue

Competitively block the thiamine transporter of Eimeria species

Control and treat coccidiosis in Calves, sheep, goat, puppies and birds

For Prophylaxis
Cattle @ 5mg/kg PO 21 days

For Treatment
Cattle @ 10 mg/kg PO for 5 days in feed or water

Cat @ 60-100 Total PO 7 days

Dog @ 100-200 mg in food PO 7 days

Poultry @ 0.012-0.24% PO in water for 3 days


Maximum Dose
Large animal 200 mg
Small animal 100 mg

Not used in puppies with 20 days of age

Excess dose in sheep cause encephalomalaciae
Calves - inhibit erythrocyte production
Toxicity at high dose

Amprolium powder 150g, 1kg

Amproforte (Amprolium fortified with vitamin) 100g, 1kg

Anticoagulants

Inhibit ketolase enzyme in the glucolytic pathway

Anticoagulant of glucose level in blood

6-8mg/ml blood or 2.5mg per ml of blood

Anti diarrhoel

Inhibits clotting by activating your body's antibody process

To prevent/tract contain blood vessel, heart, lung condition, prevent blood clotting during open heart surgery, bypass surgery, kidney dialysis and blood transfusion

Dog and cats: anticoagulant 1-2 units/ml of blood reaction of thromboembolium in pulmonary: 200-500 IU/kg

I/M heparin odministration - hematoma formation

CI on bleeding and renal dysfunction

Blood in urine, coughing in blood, headache

Heparin sodium 1ml vial 5000 UPS/ml (or) 1000 UPS/ml

Thrombophob gel 20g(zydur) 

ALPARIN injection 5 ml vial (5000 IU/ml) 

ALPARIN injection 5 ml (25000 IU/ml) 

Chelating class of drug

Category'B' drug

Bind with available ca2+ and prevent further toxic effects of toxin

Bind with ca2+ so prevent the coagulation of blood

Used in reaction of heavy metal toxicity like Pb, Zn

Used in cosmic and food industries and with in scientific laboratories

Lead poisoning- (20ug/dL-70ug/dL) - 1000mg/M2 daily given IV or I'M

If lead poisoning > 70ug/dL

EDTA is combined with dimer caprol i. e. EDTA is administrated before dimercaprol

Adult with Nephropathy :- 500mg/M2 for every 24 hours for 5 days

Pediatric dosing:- chelation therapy is necessary in patients with blood lead levels over 45 mg/dL. If lead poisoning- 45 ug/dL to 70 ug/dL =>25 mg/kg/day for 5 days

If lead poisoning > 70 ug/dL=> IV administration of EDTA at 50 mg/kg/day in 6 doses 

In children with cerebral edema

=> IV is avoided due to increase in intracranial pressure so we can go for  I/M in that patients

•Renal toxicity

• Weight loss due to Zn deficiency

•Nausea 

• Vomiting, chills, fatigue tremors, anemia

• Use of Na EDTA can cause severe hypocalcemai 

Na+ EDTA, ca+ EDTA

Livodate Ca 20 (200mg/ml)

1. Parasympathomimetic agent

• Reversible inhibition of ache enzyme
• Direct interaction with cholinergic receptors

• Rumen atony
• Initiating peristalsis
• Emtying bladder 
• Stimulating skeletal muscle contractions
• Ivermectin overdoses in cats

• Ruminants: 0.02 mg/kg  Single dose SC
• Horse 0.004-0.02 mg/kg SD  6 Hrs interval  SC
• Small animals: i) 2 mg/kg/day  PO  (in divided doses)   ii) Antimyasthanic: 10mcg/kg IM SC   iii) Antitode for non depolarising NM block : 40 mcg/kg IM SC

Patients with

• Peritonitis
• Mechanical intestinal or urinary obstructions
• Epilepsy, bronchial asthama, cardiac anthymias, hypothyroidism, vagotonia or megacolon

Cholinergic crisis

• Inj. Neostigmin 1 ml & 5 ml (0.5mg/ml) 
• Inj. Tilstigmin 5 ml (0.5 mg/ml) 

Anti bloat

Deforming action is by preventing formation of mucus surrounded gas pockets in GIT

Bloat, tympany

Cattle @ 100ml

sheep & goat @ 20ml

Bloatosil (VETOQUINOL) 100ml and 200ml bottlle (1000mg/100ml)

gastina (VIRBAC) 100 ml bottle (50mg/5ml)

Syr tymfree 100 ml

Cymbi drops 40gm

Blucil - 200 ml

Anti-arrhythmic 

• Calcium channel blocker
• Reduce heart rate and Blood pressure
• Dilate peripheral arteries thus decrease resistance afterload 

• Supraventricular arrythemis 
• Hypertrophic cardiomyopathy
• Hypertension

Dog= 0.5-2mg/kg T/D                                                                                           0.5-2.5 mg/kg B/D

• CHF
• Hepatic disease
• AV block
• Hypertension

• Swollen hands 
• Itching
• Stomach pain
• Constipation 

• Dilzem - 30mg,60mg tab.
• Dilgard - 30mg,60mg,90mg tab.
• Dilcal - 30mg, 60mg tab
• Diltime - 30mg, 60mg tab

Local anaesthetic and anti-arrhythmic

Reversible blockage of sodium channel receptor

Local or regional and analgesia

Arrhythmia associated with digitalis

Cat @ ventricular arrhythmia- 0.25-2.0 mg/kg IV slowly 

Horse @ 1.3mg/kg as bolus 

dog @ local anaesthesia - 4ml/kg and ventricular arrhythmia- 2mg/kg IV bolus

Hyper sensitivity to amide class local anaesthetic

Rapid infusion call CNS seizures

Extra dosage cause hypotension 

Inj Xylocard 2% - 50ml

Inj xylocaine 2% - 100ml

Gel lignocaine 30gm

Inj lidocaine 30ml (20mg/ml)

Inj easycainne 2% 30ml (20mg/ml)

Cream easycainne 30gm

Anti-Ulcer drug

Proton pump inhibitor

Gastric and duodenal ulcer, peptic ulcer, acid reflux, erosive esophagitis. 

• Dog> 0.5-1.5mg/kg   IV, PO, BD
• Cat> 0.75-1mg/kg PO, OD
• Horse> 1-4mg/kg  PO, OD

Renal failure. 

Hypersensitivity to the drug. 

Vomiting, decreased appetite, gas and diarrhoea

Kick-ulcer(37%)-oral paste-

• 6. 15 gm

Lomac capsule

• 10 mg
• 20 mg

Inj Ocid

• 40 mg vial
• IV

Tab ocid

• 10 mg, 20 mg

10 mg, 20mg, 40 mg capsule and 40 mg vial( IV) are available by the trade name of Losec, Gastrogard, Zanpro, Meprasec

Reversible H2 receptor antagonist

Inhibit the secretion of gastric acid

Gastritis, Peptic ulcers

Cats @ 2.5mg/kg PO IV IM

Dog @ 5-10mg/kg BID PO IV IM

Constipation

Diarrhoea

Skin rashes

NA

Tab Cimetidine 200 mg

Tab Ulciban 200 mg and 400 mg

Tab Tymidin 200mg and 400mg