Antidiabetic

Second gen. Sulphonyl urea, pancreatic and extrapancreatic effects 

Stimulates insulin secretion in cats with functional beta cells, Increase serum insulin concentration , Decrease serum glucose concentration

Dogs and Cats - 0.25-0.5 mg / kg B. Wt. 2 times daily 

Pregnancy ( ketotoxic)         not used in ketonuric cats 

Hypoglycemia, vomiting, Cholestasis, increased hepatic enzyme activities

Glucotrol XL, Glymase XL-5, Minodiab

Antibiotics

Aminoglycoside antibiotic inhibit bacterial protein synthesis

• Mastitis, Metritis, otitis, pneumonia, ocular infection, UTI, Pyometra, RTI, wing rot, colibacillosis, GI infection, CRD complexes

Dog-Otic - 4-8 drops 12 hrs interval ,Opthalmic-1 drop per eye 6-8 hr interval, Systemic-5-10 mg /kg wt. Slow I/V q 24 hrs

Cat-Opthalmic - 1 drop per eye 6-8 he interval , Systemic -5-8 mg /Kg slow I/V over 30 min. Or I/M or S/C - 24 hrs interval 

Birds -3-5 mg / kg Body wt. I/ M or I/V                           Chickens -0.2 mg S/C    Pheasants -5mg/kg I/M q 5h    Quail - 10 mg/kg I/m q 6h 

Cattle/sheep/gots /pigs -4mg /kg B. Wt. I/m Or I/v

Elephant -4. 4 mg/kg wt. I/m Or I/v (mix with saline before IV infusion) 

Pregnancy, Renal diseases patients with Neuromuscular disorder and in neonates  and geriatric patients. Do not use if ear tympanum is perforated

Nephrotoxicity, Ototoxicity, Neuromuscular blockage 

Inj Gentamicin

• 100 ml via
• Each ml contain 40 mg

Other brands

Vetamicin, Genta, Otomax, Tiacal, Genticin, Clinogel vet

Anti maggot

Topical skin protectant, astringent, and bacteriocidal agent

All type of maggot wound, abrasions, navel infection paws injury, dog bite, post docking lesions, scratches. Post surgical application over the surgical wound.

Dust to the powder over the area

NA

NA

Powder gotbac 20gm, 40gm (Permethrin 2% + Sulphanilamide 5% + Zinc oxide 2%)

• Sympatholytic
• Alpha2-adrenergic antagonist

• Non selectively antagonizes Alpha2-adrenergic receptors

• Reverse the action of Xylazine or detomidine

Cats and dogs @

• 0.11 mg/kg IV
• 0.25-0.5 mg/kg SC / IM

Horse @

• 0.125 mg/kg IV (To reverse xylazine)
• 0.2 mg/kg IV (To reverse detomidine)

Cattle, Sheep & Goat @

• 0.125-0.2 mg/kg IV (To reverse xylazine or medetomidine)

• While administer monitor heart rate and rhythm carefully

• In horses- excitation, rearing, striking, muscle tremors, exaggerated response to stimuli
• Increased heart rate
• High doses- tremors and seizures

Inj Yobealth

• 30 ml vial
• Each mg contains 10 mg

Inj Yohimbine VetUp

• 10 ml vial
• Each ml contains 2 mg

Anti-ulcer (Proton pump inhibitor)

• Inhibit gastric acid secretion by inhibiting the K+/H+ pump

• Treatment and prevention of GI and duodenal ulcers
• Chronic acidity
• Gastritis
• GERD with history of Erosive esophagitis
• Pathological hypersecretory conditions

Cats and dogs @

• o.5-0.6 mg/kg once daily PO
• o.5-1 mg/kg IV

Large animal @

• No dose reported for large animals
• Dose have been extrapolated from human use (o.5 mg/kg q24h IV)

• Hypersensitivity to serratiopeptidase
• Concurrent use with anti-fungal may reduce the absorption 

N/A

Inj P-PPi 40 mg

Inj Pantop 40 mg

Inj Pantocid 40 mg

Inj Pantofit 40 mg

Tab Pantop 20 mg, 40 mg

Tab Pantocid 40 mg

Tab Pantofit 40 mg

Pancreatic hormone

Initiate its action by binding to cell surface receptors that stimulate the formation of glycogen in liver, lipid from fatty acid and protein from amino acids

• Adjunctive treatment of diabetic ketacidosis, uncomplicated diabetes Mellitus, adjunctive therapy of hyperkalemia
  
  

Insulin preparations-

• Regular nsulin
• Neutral protamine hagedorn (NPH)
• Lente insulin
• Ultralente insulin
• Vetsulin
• Protamine zinc insulin (PZI)
• Glargine insulin (Lantus)

Dosage

Cat @

• Short - acting regular insulin . Treatment of ketoacidosis : 0.2 unit / kg IM initially , then 0.1 unit / kg IM every hour until glucose level is less than 300 mg / dL and then continue with 0.25-0.4 unit / kg SQ q6h
• NPH not recommended for cats , but has been used at 0.25 units / kg SQ q12h or 1-3 units per cat SQ q12h
• Protamine zinc recombinant human insulin ( ProZinc ) : Start with 0.2-0.7 units / kg every 12 hours SQ . Adjust dose to achieve nadir of glucose of 80-150 mg / dL .
• PZI insulin : Initial dose is 0.5 unit / kg SQ and then once or twice daily ( usually twice is needed ) with subsequent doses adjusted to produce desirable glucose levels , usually no higher than 3 units per cat . Final adjusted dose for most cats is 0.9 ( 0.4 ) unit / kg .
• Glargine insulin : Start with 0.5 unit / kg q12h SQ . Some cats can be managed with once - daily dosing , but twice daily is preferred . Adjust dose via monitoring . If treating diabetic ketoacidosis , one may start with glargine insulin administered intramuscularly , then switch to SQ injections for maintenance
• Detemir insulin : Use same dosage regimen as for glargine insulin 

DOG @

• Short - acting regular insulin . Treatment of ketoacidosis for dogs 3 kg : 1 unit / animal initially , then 1 unit / animal q1h ; for dogs 3-10 kg : 2 units / animal initially , then 1 unit / animal q1h ; and for dogs > 10 kg : 0.25 unit / kg initially , then 0.1 unit / kg q1h IM . 
• NPH for dogs < 15 kg : 1 unit / kg q12-24h SQ ( adjust dose with monitoring ) dogs > 25 kg : 0.5 unit / kg q12-24h SQ ( adjust dose with monitoring ) . 
• Vetsulin : Initial dose 0.5 unit / kg , once or twice daily , SQ . Adjust dose ( increase or decrease of 25 % of dose ) by monitoring .
• PZI human recombinant : Can be used as an alternative to beef / pork PZI insulin . Start with 0.5 units / kg , SQ q12h . Median dose in well - controlled dogs is 0.9 units / kg ( range 0.4-1.5 units / kg ) SQ q12h 
• Glargine insulin : Start with 0.3 units / kg SC q12h . Then monitor glucose to adjust dose . The dose range in well - regulated dogs is 0.32-0.67 units / kg q12h SQ .
• Detemir insulin : 0.12 units / kg , SQ , q12h , ( adjust dose as needed ) . Because of small dose in dogs , a specific diluent may be needed to obtain accurate dose in small dogs .

• Ruminants: 200 IU total dose   SC
• Horse: 0.15 unit/kg, 12 hrs, IM SC

• Episodes of hyperglycemia
• Lipo dystrophic reaction occurs at injection site
• Don't use without ability to monitor glucose in animals because of risk of hypoglycemia
• Don't mix regular insulin with insulin containing zinc --- prolong absorption

• Overdose - Hyporglycemia
• Insulin induced hyperglycemia
• Insulin antagonism/resistance
• Local reaction

• Inj. Prozinc 10 ml (40 units/ml) 
• Inj. Lantus (insulin glargine rDNA insulin) 100 units per ml

Antibiotics

Block the sequential steps in synthesis of tetra hydrofolate, a cofactor required for the synthesis of many molecules including nucleic acids

effective against nocardia brucella Gram Negative some gram Positive organisms, pneumocystis carinii,Toxoplasma gondii and other coccidians

Dog -15 to 30 MG per KG po q 12 hr interval, Cat -UTI -30 mg/Kg PO  OD for 7-14 days, soft tissue infection -15 mg/kg PO BID for 28 days, Horse - 15 to 30 mg/kg  IM, Slow IV q 12-24 hrs, pig- 15 to 30 mg/kg IM PO q 24 hrs, cattle - 25 mg/kg IV, IM, OD, calves -48  mg/kg OD IV , IM Sheep and goat- 15 to 30 mg/kg IM, IV, q 12 to 24 hrs, elephant-22mg/kg PO 4 days

Avoid animals having keratoconjunctivitis Sicca    polyarthritis

Keratoconjunctivities sicca (dry eye), hemolytic anaemia, cholestasis, polyarthritis

V vozine powder 100g, 750g( sulphadiazine & trimethoprim)                          Bolus ; Bactrim DS (160 mg trimethoprim and 800mg sulfamethoxazole   susp Bacteim 50 ml( each 5ml contains trimethoprim 40 mg and sulphamethoxaxole 200mg)                                        Intrauterine oriprim u bolus (trimethoprim & sulphamethoxaxole)            oriprim bolus 2.4g ( trimethoprim&  sulphamethoxaxole       

Analgesics

Opoid receptor agonist

Relieve mild to moderate pain, chronic pain from osteoarthritis & neoplasia, cough in dogs

Dog -2 to5 mg/kg po q 6- 8 hrs, 2 mg/kg IV                     Cat - 2 to 4 mg/ kg PO q 12 hrs, 1- 2 mg/kg IV, SC           Horse - 10 to 24 mg/kg PO BID

Epilepsy                                       High doses - teratogenic Or fetotoxic                                dysphoria in cats

At high dose it maybe teratogenic or fetotoxic 

Tab TRAMSIL                             Tab TRAMADOL 50 mg, 100 mg                                          inj. TRAMADOL - 50mg/ml

Insecticide

Acetylcholinestrase,damage DNA of insect

Intestinal parasites

Dog= 100mg/kg

Dog have constipation

• Vomiting
• Diarrhoea
• Drowsiness
• Fatigue
• Headache

• DEROXA
• NUVAN

Hormone

Negative feedback to gonadotropin secretion. 

Estradiol mediates luteolysis via PGF 2 alpha

• Estrous induction
• Treatment of vaginitis 

• Estrous induction- 5mg/day PO
• Vaginitis treatment- 0.5-1 mg/animal for 7 days

Do not use in cats

Structural anomalies of reproductive organs

• STIBROL (10ml)
• ESTIROL (10ml)
• DIBESTROL (10ml)
• STILBEST (10ml)