Chelating class of drug

Category'B' drug

Bind with available ca2+ and prevent further toxic effects of toxin

Bind with ca2+ so prevent the coagulation of blood

Used in reaction of heavy metal toxicity like Pb, Zn

Used in cosmic and food industries and with in scientific laboratories

Lead poisoning- (20ug/dL-70ug/dL) - 1000mg/M2 daily given IV or I'M

If lead poisoning > 70ug/dL

EDTA is combined with dimer caprol i. e. EDTA is administrated before dimercaprol

Adult with Nephropathy :- 500mg/M2 for every 24 hours for 5 days

Pediatric dosing:- chelation therapy is necessary in patients with blood lead levels over 45 mg/dL. If lead poisoning- 45 ug/dL to 70 ug/dL =>25 mg/kg/day for 5 days

If lead poisoning > 70 ug/dL=> IV administration of EDTA at 50 mg/kg/day in 6 doses 

In children with cerebral edema

=> IV is avoided due to increase in intracranial pressure so we can go for  I/M in that patients

•Renal toxicity

• Weight loss due to Zn deficiency

•Nausea 

• Vomiting, chills, fatigue tremors, anemia

• Use of Na EDTA can cause severe hypocalcemai 

Na+ EDTA, ca+ EDTA

Livodate Ca 20 (200mg/ml)