Alter the cellular membrane of fungi increasing membrane permeability allowing leakage of cellular contents and impaired uptake of purine, pyrimidine precursors
Indication
Aspergillosis
Cryptococal meningitis
Blastomycosis and histoplasmosis
Candidiasis or dermatophytosis
Sporotrichosis
Coccidioldes Immitis osteomyelitis
Dose
Horse: 3-5 mg/kg 12-24 ht PO
Dog: 2.5 mg/kg PO 12 hrs or 5 mg/kg 24 hrs PO Dermatophytes: 3mg/kg/day PO for 15 days Malssezia: 5mg/kg/day 24hrs PO