1. Parasympathomimetic agent

• Reversible inhibition of ache enzyme
• Direct interaction with cholinergic receptors

• Rumen atony
• Initiating peristalsis
• Emtying bladder 
• Stimulating skeletal muscle contractions
• Ivermectin overdoses in cats

• Ruminants: 0.02 mg/kg  Single dose SC
• Horse 0.004-0.02 mg/kg SD  6 Hrs interval  SC
• Small animals: i) 2 mg/kg/day  PO  (in divided doses)   ii) Antimyasthanic: 10mcg/kg IM SC   iii) Antitode for non depolarising NM block : 40 mcg/kg IM SC

Patients with

• Peritonitis
• Mechanical intestinal or urinary obstructions
• Epilepsy, bronchial asthama, cardiac anthymias, hypothyroidism, vagotonia or megacolon

Cholinergic crisis

• Inj. Neostigmin 1 ml & 5 ml (0.5mg/ml) 
• Inj. Tilstigmin 5 ml (0.5 mg/ml)