Fluoroquinolones antibiotics

• Inhibits specific bacterial enzymes (bacterial topoisomerase IV and DNA gyrase) needed for the bacteria to replicate and repair its DNA.
• Synthetic broad spectrum antibiotic with antibacterial activity against a wide range of bacteria including pseudomonas, staphylococcus, haemophilus, Enterobacter and E. coli. 

• Superficial skin infections (pyodermas)
• Respiratory infections
• Haemorrhagic Septicemia
• Bovine Respiratory Disease
• Pneumonia and Bronchopneumonia
• Acute & Chronic Mastitis
• Urinary bladder, kidney, prostrate, skin infection.

Cat - 2 mg per KG (IV, SC,oral ).

Dog-2 mg per KG (IV, IM,SC)

• 9kg (20lb)                half 50mg tablet
• 18kg (40lb)              one 50mg tablet
• 36kg (80lb)              two 50mg tablets

Poultry - 2mg per kg(Oral).

Conditions

• Mastitis: Daily dosing @ 2mg/kg B.wt. (1ml/50kg B.wt.) for 3 to 5 days
  by IV/IM/SC route.
• Respiratory Disease: Single shot @8mg/Kg B.wt. (4m/50kg B.wt.)
  by IM route

• Allergic 
• Animal which has GIT problem.
• Kidney or liver disease or a central nervous system disorder
• Under one year age.
• Pregnancy -Fetotoxicity

• Fetotoxicity
•  Nausea, vomiting, loss of appetite, increased thirst, diarrhoea and lethargy. 
• Convulsions or seizures are a rare side effect in pets with CNS disorders.

Inj Marbomet 30 ml (100mg/ml) (INTAS)

Tab Marbomet - 50 mg

Marbomet tablets 50mg  once daily with or without food, preferably at the same time each day.

Antibiotics (2nd gen. flouroquinolone) 

• Bactericidal
• Interferes with action of DNA gyrase (Topoisomerase II)  which inhibits the replication of bacterial DNA

• Urinary, genital, gastrointestinal tract and soft tissue infections

Cat & dog @ 22mg/kg  12hrs    PO

Birds @ 10 mg/kg Po OD

• In young animal - Cartilage injury
• Animal prone to seizures

• Spontaneous tendon ruptures
• Hepatotoxicity
• Allergic neuropathy
• At high doses, cause nausea, vomiting, and diarrhea.
• Arthropathy in young animals

Tab. Norflox 100mg, 200mg, 400mg

Tab Normax 400 mg

Susp Bacigyl 30 ml (Each ml contains 20 mg)

• Fluoroquinolones

• Broad spectrum antibiotics

Bactericidal drug

Inhibition of Deoxyribonucleic acid gyrase this inhibit both DNA and RNA synthesis

For the treatment of bacterial infection of alimentary canal and respiratory tract, skin infection

acute and chronic mastitis, wooden tongue, brucellosis, pyometra, bq, hs, otitis

wound, secondary bacterial infection associated with virus, urogenital infection

fowl cholera, infectious coryza, crd, pasteurellosis

Dog=> 5-20 mg/kg of body weight

Sheep, cattle=> 2.5-5 mg/kg body weight

Goats, pig=> 10 mg/kg body weight

Poultry=> 10-12 mg/kg (orally) 

Contradicted in young ones 12 month in small breeds of dog and 18 months in large breed of dog

• cartilaginous growth

• Epilepsy

• Gestation and lactation

Nausea, vomition, loose stools, allergy Or hypersensitivity

Meriquin - Syr 100ml and 500 ml (VETOQUINOL)

Meriquin vet - Inj 100 ml (100mg/ml) (VETOQUINOL)

Meriquin vet - Tab 50mg and 150mg (VETOQUINOL)

Inj fortivir (VIRBAC) - 10ml, 30 ml 50ml and 100 ml vials (100mg/ml)

Inj flobac sa (INTAS) - 30 ml vials (100mg/ml)

inj enrox (ALEMBIC) - 30ml vials (100mg/ml)

Quintas - Inj 15, 50 , 100 and 1000ml (100g/ml)

Enrocin - Inj 15ml and 100 ml (100mg/ml) and Tab 150mg

Enrobest Inj 15ml and 100 ml

Enbact - Inj 20ml, 100ml

Enrotreat - Inj (15ml, 50ml, 100ml) and Solution (500 ml and 5000ml)

Fluoroquinolone

Inhibits supercoiling of DNA in the bacteria, producing bactricidal action.

Respiratory tract and urinary tract infection in cats and dogs

Glasser’s disease in horse

Infectious Coryza, colisepticemia, CRD, salmonellosis, fowl cholera

Cat & dog @ 5-15mg/kg PO IM IV

Cattle & sheep @ 4-5mg/kg PO IV IM

In Young ones cause arthropathic effects

GI disturbances 

CNS disturbances and rashes

Cflox Power - Inj 50 ml vial (100mg/ml) (INTAS)

Bilcipro - Inj 100mg/ml (30ml)

Ceflox vet - Inj 40mg/ml (30ml)

Ceftak - Bol 2.5gm

Ciprovet - Bol 2gm and Inj 10ml, 30ml, 50ml (40mg/ml for all)

Ciptec vet - Inj 30ml (40mg/ml)

Quintor -  Tab250mg and Inf 100ml (2mg/ml)

Cifran - Tab 250mg and Inf 100ml (100mg/50ml)

Ciprobid - Tab 250mg  and Inf 100ml (2mg/ml)

Third generation cephalosporin 

B-lactam antibiotic

Interfere with production of cell wall peptidoglycan cause lysis of cell wall.

Ceftizoxime does not get deactivated by hydrolytic enzymes as it lack C-3 side chain

Mastitis

Large - 5mg/kg single dose (for 96hours)

Inj Zoctim (INTAS) - 2.5gm and 3gm vials

inj voxim (VETOQUINOL ) - 2.5gm and 3gm vials

inj M-ceft (ALEMBIC) - 2.5gm vials

Third generation cephalosporin 

Binds to penicillin binding proteins which inhibit final transpeptidation and cause lysis of bacteria cell wall

Respiratory and uninary tract infection 

Cattle @ 1.1-2.2 mg/kg IM

Horse @ 2.2-4.4 mg/kg IM

Sheep & goat @ 1.1-2.2 mg/kg IM

dog @ 2.2 mg/kg SC

Xyrofur - Inj 0.25gm, 0.5gm and 1gm vial (INTAS)

wofur - Inj 1gm (VETOQUINOL)

Xyrofur Tazo - (Ceftiofur + tazobactam) - inj 1.125 gm vial (INTAS)

Xcefet (ALEMBIC) - Inj 500mg and 1gm vials

Bovicef

Inj 500mg and 1gm

Ceftivet 

Inj 1gm and 4gm

Xnel

Inj 1gm and 4gm

Third generation cephalosporin 

Binds to penicillin binding proteins which inhibit final transpeptidation and cause lysis of bacteria cell wall

Haemorrhagic septicemia, animal black quarters, cystitis, nephritis, meningitis, metritis, mastitis, pyometra, preoperative prophylaxis, post operative care

Small animal @ 10-15 mg/kg IM IV

Large animal @ 5-10 mg/kg IM IV

Penicillin hypersensitive animals

Cause cross resistance in penicillin hypersensitive animals

Inj gardplus (VIRBAC) - 4.5gm vials ( 3000mg cefoperazone + 1500 mg sulbactam)

Cefevel - Inj hug and 2g

Zosul - Inj 1g

Ceftas - SB - Inj 500mg, 2g, 3G and 4.5 g

Semi synthetic beta lactamase inhibitor

Irreversible inhibitor of beta lactamase 

Exerting its action by binding with these enzymes and blocks their destructive hydrolytic activity.

Mastitis, Pneumonia, Peritonitis, H.S.

Cat & dog @ 15-25mg/kg IV IM

Sheep and goat @ 10-15 mg/kg IV IM

Large animals @ 5-10mg/kg IV IM

Penicillin hypersensitive animals

Cause cross resistance in penicillin hypersensitive animals

Inj Wocef x ( VETOQUINOL)

• 3.375g and 4.5 gm vials

Inj Intacef tazo (INTAS)

• Inj 562.50 mg, 2250mg, 3375mg, 4500mg

Vetaceph tazo

Inj 3375 mg

Vetazo

Inj 2250 and 3375mg

Third generation cephalosporin 

Beta lactam antibiotic that produce bactericidal action by interfering with production of cell wall peptoglycan causing cell wall lysis.

Metritis

mastitis

pyometra

endometritis

nephritis

endometritis

osteo arthritis

HS

Small animal @ 15-25 mg/kg IM IV SC

Large animal @ 5-10 mg/kg IM IV SC

Penicillin hypersensitive animals

Cause cross resistance in penicillin hypersensitive animals

Wocef (VETOQUINOL) - 500mg, 3 gm and 4 gm vial

Axone - Inj 0.5g, 2gm, 3gm (CADILA)

 Cefcare - Inj 500mg

Cefstan - Inj 500mg and 3gm

 Cefzon - Inj 3gm

Cencef - Inj 3gm

Ciplacef - Inj 3gm

 Haxone - Inj 0.25, 0.5, 1, 2,3gm

 Intacef - Inj 0.25, 0.5, 1, 2,3,4gm (INTAS)

 Lyxaceft - Inj 3gm

Moxef - Inj 250mg, 2g, 3G

 Novicef - Inj 3gm

Safevet - 3G

 Seftrivet - Inj 3gm, 4gm

TT cef - Inj 0.5g and 3gm

 Tricef - Inj 3gm

 Vetaceph - Inj 1, 2 ,3 4gm

Third generation cephalosporin 

Binds to penicillin binding proteins which inhibit final transpeptidation and cause lysis of bacteria cell wall

Respiratory tract infection, Urinary tract infection, Localied infections, tuberculosis

Cat & dog @ 25-50 mg/kg IM IV (divided dose)

Penicillin hypersensitive animals

Cause cross resistance in penicillin hypersensitive animals

Britax

Inj 250mg, 500mg, 1g

Cefotaxime

Inj 250mg, 500mg, 1g

Crilcef

Inj 3gm

Haltax

Inj 2g

Lyfovet

Inj 2gm and 4gm

Taxim

Inj 125mg, 250mg, 500mg, 1gm, 2gm