Antiviral Drugs

Inhibits viral replication ( viral DNA polymerase) depends on viral thymidine kinase for phosphorylation. 

Ocular Feline Herpes virus (FHV-1) 

Cats - q4 - 6h  small amount to affected eye (max -3 weeks) 

Ocular irritation

Hepatic dysfunction, Myelosuppression ,        CNS effects - convulsions,  coma, Fever, Phlebitis. 

Simplovir eye gel - 5g

Natclovir -  250 mg capsule

Virson gel -  5g

Natelovir -  500 mg tab

Gancigel eye ointment- 5 g

Clygan gel 1.5g

Anti viral drug - Purine analogue 

Synthetic guanosine nucleoside analogue substitute guanosine in DNA synthesis and inhibits viral replication

• Herpes viral infection

Birds @ 80 mg/kg PO 3 times daily

Horse @ 10 mg/kg Slow IV 2 times daily

Dogs and Cats @ 3mg/kg PO 5 times daily for 10 days and upto 10 mg/kg PO 5 times daily for next 10 days

10-20 mg/kg slow IV infusion 3 times daily

• Renal impairment
• Dehydration 
• Hypersensitive patient

Oral - GI disturbance

IV - Renal insufficiency in dehydrated state

Topical - Local irritation

Tab Herperax 400 mg

Tab Zovir 200 mg

Cream Acivir 5%

Gel Cyclovir 5 % 

Antitussive

• Non competitive NMDA receptor antagonist
• Nicotinic cholinergic receptor antagonist
• Raise threshold of cough centre

• Cough suppression
• Chronic bronchitis

• Dog/Cat= 1-2mg/kg PO or T/D
• Cattle= 5-15mg/kg

• Pneumonia
• Lung disorder

• Slowed breathing
• Blurred vision
• Drowsiness

Tab. DMR 20 - 20mg

Antitussives 

Opioid antitussionves, selective full agonist of Mu opioid receptor 

To treatment of moderate to severe pain, cough, dyspnea

0.25mg/kg P/O TID

Chronic dung disease, obstructive pulmonary disease, pregnancy, bowel obstruction, increased intracranial pressure

Increase intracranial pressure 

Hysingla, zohydra(tablets) 

Analgesics, Antitussives

Opoid analgesic

Agonish K opoid receptor

Partial agonist of mu Receptor

Pain, combination with metdetomidine for sedation

Antitussive for chronicnon productive cough

Visceral pain, Colic in horse

In cats, combination with medetomidine and Ketamine by IV route to induce anesthesia of short duration

Dose 

Pre anesthetic

Dog

0.2 -0.4mg/Kg IM, SC

0.05mg/kg IV

Cat

0.4mg/kg SC IM

0.1mg/kg IV

Horse 

0.01 -0.06 mg/Kg IV

0.013 - 0.024 mg/Kg hr infusion

For Analgesia

Dog

0.2 -0.3 mg/kg SC, IM, SC

1- 4 mg/Kg PO 4 times daily

Cat

0.2 -0.4 mg/Kg SC IM

0.1 mg/Kg IV

1.5 mg/kg  PO 6 times daily

Ruminant

0.05 -0.2 mg/Kg 

Pig

0.1 -0.3mg/kg

Dog & Cat

0.2 - 0.4mg/kg IV (loading dose) followed by 0.1 -0.2 mg/kg /hr IV infusion

Horse

0.02 - 0.04 mg/Kg IV repeated after 3 -4 

0.04 - 0.2 mg/Kg IM repeated after 3-4 hr

Antitussive dose

Dogs 0.2 - 0.5 mg/kg

Neurolept analgesia

Dog & Cat

0.2 -0.4mg/kg IM combination with medetomidine (0.01mg/kg)

Horse

Ataxia, CNS exitement, Lower respiratory diseases, Bradycardia, Vomiting, Pregnancy

Ataxia, CNS exitation

High doses - Nystagmus, Salivation, Seizure, Hyperthermia, decreased GI motility

Inj Butdol 1mg/ml

Inj butdol 2mg/ml

Anti-spasmodic

Block the effect of Ach and inhibit the involuntary detrusor muscle contraction of urinary bladder. 

Stops bladder spasms

Dog - 0.2mg/ kg  PO, BD   Or 1.25-5mg total dose/dog

Cat- 0.5-1mg total dose/cat PO, BD

Gastric dysmotility, urinary bladder obstruction urinary retention

Urinary retention, excessive salivation, sedation, carstipation

Tab. oxyspas-2. 5mg, 5mg

Tab. Cystran- 2.5mg , 5mg

Tab. Tropon XL 5-5mg

Antiseptic

More active against G+ve bacteria, alkaline medium enhances activity and opposed by hypochlorites, act on pus filled cavities

To clean pyogenic cavities, acriflavin gel g used to treat burns

N/A

Carcinogenic

N/A

Ointment Lorexane 30gm and 100gm

Antiseptic 

Azodyes

Effective against gram negative bacteria

5% ointment on sores, ulcers, wounds

used as 5% ointment

Uncoordinated movements

Irregular twist

Colored skin

Antiseptics

Penetrate microorganisms and oxidises proteins in microorganisms

Used also as disinfectant in topical prophylaxis, for superficial infection by gram negative & gram positive bacteria

NA

Hypersensitivity

Thyroid problems                   soreness of teeth and gum   , stomach upset

2% iodine, 2.4% NaI dissolved in 70% ethanol

Antiseptic

Effective against bacteria fungi ,yeast and viruses at concentration of 0.001% -0.003% and sporocidal 0.25 -0. 5%

Solution of peracetic acid will be helpful in reducing microbes in severely contaminated conditions 

No infusion available

N/A

Severe irritation

N/A