NSAIDS

Inhibits COX-2  enzymes 

Limits production of prostaglandins.

Post-operative pain 

Reduce inflammation

Reduce pain

Cattle @ 0. 5 mg per KG(IV ,IM)

• 1ml/10 kg kg bwt in mastitis, pneumonia, uterine prolapse and surgical interventions
• 1ml/25 kg bwt for musculoskeletal disorders, otitis, FMD and inflammatory conditions

Sheep and goat @ 1mg /kg (IV ,IM).

Horse @ 0.6 MG per kg bwt.

Dog @ 0.2 to 0.3 mg per kg bwt

Cat @ -0.2 MG per kg bwt.

Dehydration, hypovolaemic pressure hypo intensive patients,Late gestation,less than six week age.

Ulcer

Inj Melonex (INTAS)

• 15ml, 30ml and 100ml vials
• Each ml contains 5 mg

Bolus Melonex (INTAS)

• Each bolus contains 100 mg
• Large animals @ 2 bolus/400 kg bwt daily
• Small animals @ 1/4-1/2 bolus daily orally

Inj Melonex Power (INTAS)

• 30ml, 100ml vials
• Each ml contains 20 mg meloxicam + 1% w/v lignocaine

Melobest

Melobest P

NSAIDs

• Inhibit CoX-1 and CoX -2 So producing less amount of Prostaglandin. 
• Antipyretic, anti-inflamatory and analgesic effect. 

Relieve pain, tenderness, swelling and stiffness. 

Dog- 2mg/kg  IV, SC, IM,OD.

        1mg/kg  PO, OD

Cat -2mg/kg SC

          1mg/kg PO

• Hypovolemic/Hypotensive patients. 
• Dehydrated animals. 
• Cats show adverse effects 

• Vomiting
• Diarrhea
• Inappetence,
• GI Ulceration,
• Mild liver inflammation. 

Inj. Neoprofen

• 1% w/v
• 15 ml, 100 ml vial

Inj. Vetprofen

• 1% w/v
• 15 ml vial

Inj. Ketofen

• 100 ml vial
• 100 mg/ml

Inj. Profen

• 100 ml vial
• 100 mg/ml

NSAIDs

Cox Inhibitors

Anterior uveitis

Ulceration keratitis (when topical corticosteroids are contraindicated)

Cat & dog @ 1drop per eye at 6-24hr interval

As an analgesics @ 0.25mg/kg IM BID/TID in cats and 0.3-0.5 mg/kg IV IM BID/TID in dog

Renal disease

• This may cause the eye to sting for a short period after application
• This can affect and delay wound healing
• This can affect platelets causing an inability to clot blood
• This can cause local irritation resulting in redness and irritation of the tissues surrounding the eye

Ketodrops LS 5ml

Tab kelac 10mg

Inj ketorol 1ml (30mg/ml)

NSAIDs

Prostaglandin synthesis inhibitor

Anterior Uveitis

Ulcerative kerotitis

Dog and cats 

Opthalmic 1 drop/eye 6-10 hrs (q) 

Presurgery : 1 drop q 30 min for 4 doses 

Allergy to NSAIDs

Allergy to NSAIDs

Eye drops flurbin (5ml) 

Eye drops ocuflur (5ml (0.03%) 

NSAIDs

Non selective cox inhibitors

• Inflammation and pyrexia associated with Bovine Respiratory disease
• Metritis
• Endotoxemia
• Acute bovine mastitis
• Musculoskeletal disorders
• Colic in horses.

Horse-

• 1 ml/45 kg
• 1.1 mg/kg q 24 hrs 5 days I/V I/M

Cattle, Sheep & Goat -

• 1ml to 2ml per 45 kg b.wt. by slow IV or IM route. 
• 1.1-2.2 mg/kg slow I/V -3 days 

Cat and Dog - 7.1mg/kg I/V I/M slc

Pregnant animal (late gestation) 

Gastritis and ulceration in prolonged use

Inj Unizif 20ml & 100ml vials (50mg/ml) (INTAS)

Inj megludyne 20ml and 100 ml vials(50mg/ml) (VIRBAC)

inj flumine 100 ml vials (50mg/ml) (ALEMBIC)

Inj flunimeg 10 ml (50mg/ml) 

Inj finadyne 20 ml (50mg/ml)

Propionic acid derivatives (NSAIDs)

Inhibition of cyclo oxygenase, phospho lipase a2 , and prostaglandin synthesis.

Chronic inflammation 

pyrexia

pain

Dog @ 2-4mg/kg

Animal with bleeding disorders

Should be cautious in renal and hepatic insufficiency.

Care O pet 

Tab 50mg

NSAID

Block cox enzymes and inhibit prostaglandins synthesis

Cataract surgery for occular inflammation and Pain

Dogs and cats

1 drop/ eye for 6-12 hrs interval

Epithelial Keratopathy

Red eyes

Rheumatoid arthritis

Megabrom eyedrops

Eynac

Nunac

Napimox

broday

Prolensa

Cromtie

Bbrom

• Rumen acidifying agent
• Antiseptic
• Disinfectant

• Rumen acidifying agent - Decrease Rumen pH 
• Antiseptic - Destroy bacteria by liberation of H+ ions

• Ruminal stasis
• Urea toxicity
• 0.25% for urinary tract irrigation
• 1-3% for burn dressing
• Surgical dressing
• 5%  for bacteriocidal to treat Otitis externa
• 33% for ringworm lesion
• 99% (glacial acetic acid) for wart destruction

Cattle @

1000-2000mL PO

Sheep @

250-500mL PO

Horse @

250ml/450kg b.wt. PO (for enterolith prevention)

• Ruminal acidosis

• Metabolic acidosis
• Corrosive action on skin and mucous membrane

NA

• NSAIDs
• Para-aminophenol derivative having analgesic and antipyretic properties 

• Inhibition of Cyclo oxygenase (COX) enzyme 
• More selectively for COX-2 than COX-1
• Anti-pyretic and analgesic effect

• Oral analgesic in dog
• Relieve pain
• Fever reducer

Dog @ 15 mg/kg PO

Calves @ 50 mg/kg PO followed by 30 mg/kg PO q6h

• Fatal for CAT (lack of Glucuronyl transferase enzyme that is responsible for metabolism of drug)
• In dog if renal or hepatic disease

• • • Can cause hepatic and renal toxicity
    •  Hb → methHb → SulfHb 
    • Haemolysis
    • Jaundice

Susp. Poenophen - 50 mg/ml (60 ml Bottle) - (MVDEX)

Infusion Rapidmol - 1%w/v (100ml Sachet) IV

Susp Calpol - 60ml

Tab Calpol - 500mg

Tranquilizer Sedative ( Phenothiazine derivative)

• Depressant effect on  CNS  
• Depressant effect on  various central neuro-transmitter receptors

• Immobilize large animals
• Skin irritation
• Pre-anaesthetic
• Sedative
• In Small animal- Anti-emetic to control vomiting associated with motion sickness

Dog @

0.1-o.25 mg/kg IM
0.025-0.2 mg/kg IV (slow)
0.25-3 mg/kg PO

Cat @

o.o5-o.1 mg/kg IM/IV
o.25-3 mg/kg PO

Cattle, Sheep & Goat @

0.03-0.1 mg/kg IM, IV, SC

Horse @

0.04-0.1 mg/kg IM, IV, SC

• Not safe in pregnancy
• Stallion with penile prolapse
• Lactating mare
• Horse dewormed with piperazine
• Sighthound & Boxer breed are sensitive (cause first degree heart block)
• Pets that have been exposed to organophosphates, strychnine, or procaine
• Trauma
• Shock

• Cause low blood pressure
• In cats, decrease tear production
• It can cause cardiovascular collapse

Tab. VETACE - 25mg

Inj. Acepromazine (VET ONE) - 10mg/ml (50ml vial)