Non elective Beta adrenergic agonist

Act by binding with specific receptors  ( adrenergic beta 1 and beta 2) 

• Acute bronchial constriction,  cardiac arrhythmias (AV block) 
• Adjunctive therapy in shock or heart failure

Small animals: 10mcg/kg 6 hrs  iM  SC

• Patients with tachycardia, AV block caused by cardiac glycoside intoxication
• Ventricular arrhythmias, coronary insufficiency, hyperthyroidism, renal disease, TBP, diabetes

• Tachycardia
• Anxiety
• Tremors
• Excitability
• Headache
• Vomiting

Direct acting Arterial and venous dialators

Nitroprusside metabolised into nitric oxide

Nitric oxide stimulate cGMP pathway producing relaxation of vascular muscles

• Hypertension
• Acute heart failure secondary to mitral regurgitation
• Refractory CHF
• In DCM with dopamine/dobulamine

Small animals: 1-5 mcg/kg/min  IV (Maximum 10mcg/kg/min) 

Patients with

• Compensatory hypertension
• Hepatic insufficiency
• Renal impairment
• Geriatric patients

• Rapid hypertension
• Irritant at infusion site
• Chronic use leads to thiocynate and cyanide toxicity

Prusid-5ml (50mg/5ml) 

Antibiotics (broad spectrum aminoglycoside) 

• Bactericidal
• Bind with 30s (stronger binded) & 50s subunit of ribosomes    a)  Interferes with formation of initiation complex of protein synthesis          OR       Inhibits protein synthesis

• Tropical preparations for skin, eyes, ears
• Oral treatment: Treatment of enteric infection and to sterile colon prior to surgery
• Orally/enema: To decrease NH3 producing bacteria in hepatic encephalopathy. 
• Antibacterial spectrum: G -ve aerobic, several G +ve     Resistance:  pseudomonas,  strepto Pyogenes

• Ruminants: 3-6 mg/kg   6-12 hours interval   PO  88 mg/kg   8 hrs interval   SC
• Horse: 2-6 mg /kg    6-12 hrs interval     PO                     4.4 mg/kg     8-12 hrs interval  IV
• Small animals: 10-20 mg/kg      6-12 hrs interval      PO

• Not safe in neonates
• Chronic use leads to superinfection
• Not safe in neuromuscular disorder, renal problems
• Horse: antibiotics associated diarrhea (enterocolitis) 

• Parentral: nephrotoxic
• Orally: ototoxicity, Nephrotoxicity, severe diarrhea, intestinal malabsorption

Spray aluspray - awd (VETOQUINOL) - 125 ml

• Inj. Neospa (140 mg/ml)   30 ml vial
• Inj. Omycin vet (140 mg/ml)   30 ml vial
• Pow. Nubiotic-SP (20% W/W)  - 50g                               Pow. Unimycin  50% - 20g
• Oint. Neosporin  5g, oint. Neosporin-H  5g, oint. Nebasulf 15g, oint vetbacin 20g

Opiod antagonist

Binding to nul, kappa, sigma opiod receptors

Reversing agent of opiod analgesia/intoxication with opiods

• Horse: 0.01-0.05 mg/kg  IV
• Small animals: 0.01-0.04 mg/kg   IM, IV, SC

• Patients with cardiac abnormalities or opiod dependent. 
• Elevate BP in endotoxic or Hypocolemic shock, strokes, spinal surgery

High margin of safety  (in usual dose) 

NA

Topical application

 It Works By Killing Sensitive Fungi By Interfering With The Formation Of The Fungal Cell Membrane And Weakening It.

• Absrasions
• Cuts
• Wounds
• FMD lesions
• Post shearing lesions
• Surgical wound dressing
• Udder impetigo

Apply topically after proper cleaning of the affected area of wound for 3-4 times a aday

Kiskin (INTAS)

• 20g, 50gm tube
• Composition-
  Clobetasol propionate 0.03% w/w
  Ofloxacin 0.1% w/w
  Miconazole nitrate 2.0% w/w
  Zinc Sulphate 3.0% w/w

Infusions

NA

• Instant replenishment of fluid
• Electrolytes and energy in conditions associated with diarrhoea
• Heat stress and debility

Cattle, Buffalo and Horse @ 500-2000 ml

Sheep and Goat @ 100-200 ml

Calf @ 100-500 ml

Dog @ 25-100

(Dose can be differ as per degree of dehydration)

IV route

intalyte (INTAS)

• 500 and 1000ml FFS Sachets
• Each 100ml contains 

Dextrose(Anhydrous) 20 gm
Sodium Chloride 0.6 gm
Potassium Chloride 0.04 gm
Calcium Chloride(dehydrate) 0.027 gm
Sodium lactate 0.312 gm

Selective mono amine oxidase type B (MAO-B) inhibitors

Increase the amount of dopamine in brain

Canine cognitive dysfunction

Memory loss

For dog and cat 0.25-0.5mg/kg PO once daily

Hypersensitive and pregnant patients

Vomitting

Lethargy

Diarrhoea

Salaivation

Tab. ANIPRYL 5mg

Cap. Selegiline HCl 5mg

Cyanide poisoning

Antidote and neutralizing agent for cyanide toxin

Cyanide poisoning

Topical treatment for ringworm

Treating side effects of chemotherapy

Hemodialysis

660mg/kg slow IV mixed with NS

60-80g PO for cyanide poisoning

In fire victim cases

Large dose at PO cause profuse diarrhoea due to saline purgative action

Sodium thiosulphate 2ml, 50ml

Powder sodium thiosulphate 227g

Saline expectorant

Cyanide poisoning

Produce methaemoglobinemia and vasodilation

Bound to methaemoglobin forms cyanomethaemoglobin

Stimulate gastropulmonary vagal reflex-expectorant

Antidote for cyanide poisoning

Expectorant

20mg/kg BW 10g/100ml distilled water repeat if therapy needed .Repeat therapy if needed 10mg/kg for every 2-4 hours

Danger in low blood pressure

Irritant action on mucosa

NITHIO DOTE

Antibiotics 

Binding to bacterial isoleucyl transfer - RNA synthesis.

Inhibiting  bacterial protien synthesis. 

Dog - staphylococcus topical infection. 

Gram + ve cocci,  Gram -ve bacteria, Pyoderma.

Dog

Ointment: Apply twice daily(10 mins - Contact time )

Hypersensitivity patients,

Extensive deep lesions

Burns.

NA

Ointment:

Mucidal -5g

T bact- 5g,

Bactroban -5g,

Staphban- 15g,7.5g.

Staphaban F -10 g.