Anti emetic,  pro kinetic 

Central D2 receptor antagonism

5HT3 Antagonism - Higher dose

At Antiemetic chemoreceptor trigger zone.

GI prokinetic effect

-local D2 antagonism

-Stimulation of muscarinic Ach and 5HT4 receptors.

Vomiting, Desophagitis,Emptying stomach prior to induction of general anaesthesia. 

Dog, cat - 1 to 2 mg/kg - (IV).

Birds-(0.3-2mg/kg) - IM

Pig - 0.5 - 1mg/ kg - (SC)

GI obstruction, perforation, epileptic patients,

Drug Interaction: Inhibited by Anti muscarinic drugs, and narcotic analgesics.

Tablets

Periorm-5,10mg

Injection 

Perinorm-2 ml(5mg/ml).

Syrup 

Perinorm- 30 ml ( 5mg/5ml).

Progesterone preparation

• Maintains the endometrium and is important for the continuity of pregnancy
• Promotes mucus formation in vagina, participates in development of alveolar system in mammary gland
• At low dose, cause ovulation

• Habitual / threatened abortions due to inadequate progesterone level
• Uterine prolapse
• Repeat breeding due to failure of embryo implantation as a result of luteal insufficiency

Route - IM

Habitual abortion indications in Early pregnancy - 3ml IM after 45 days of pregnancy and to be repeated 4-5 times at every 10 days interval

Habitual / threatened abortions ( mid / late pregnancy ) - 3ml IM for 3 days and followed by weekly injection for next 3 weeks

Uterine prolapse (due to pronounced heat) - 3 ml IM to be repeated on 3rd day, if required

Post partum uterine prolapse - 3 ml IM at every alternate day, followed by weekly injection for 3 weeks

Anti partum uterine prolapse - 3 ml IM at 2 days interval for 3 times

Repeat breeeders (with luteal insufficiency) - 2-3 ml IM at 5th, 12th and 19th days post Al .

• Prolonged exogenous administration - Uterine glandular hyperplasia, uterine fluid accumulation, endometritis
• Pregnant animal

• Pain at site of administration
• Allergic skin rashes
• Urticaria may be encountered

Inj. PROGESYN (INTAS)

• 3 ml ampoule
• Each ml contains

Hydroxyprogesterone caproate IP........0.25g
Benzyl alcohol IP........0.02ml (as preservative)

Inj. P Depot (ZYDUS)

• 2ml, 3ml ampoules
• 250mg/ml

inj duraprogen (VETCARE)

• 2ml ampoules
• 0.25gm/ml

inj gestabliss (VET MANKIND)

• 0.25gm /ml

Phosphorous binders

Control high blood levels of phosphorous in CKD

CKD

Cat @ 200mg 2-3 times daily

Dog @ 400mg PO with meals

Hypophosphatemia or bowel obstruction

Hypersensitive

Reduced apetite

Vomitting

Constipation or Diarrhoea

Tab. Sevalmer HCl 400mg and 800mg

Tab. Sevalmer carbonate 800mg

Tab. Acutrol 800mg

Renagel

Hormone

Direct luteolytic action

• Terminate pregnancy
• Estrous synchronisation
• Induction of parturition 
• Pyometra

Cattle:

•     Abortion= 25mg total dose once I/M
•     Synchronisation= 25mg I/M for 10-20 days
•     Pyometra = 25mg

Dog:

• Abortion= 0.025-0.05 mg/kg q 12hrs I/M
• Pyometra= 0.1-0.2 mg/kg S/C

Hepatic, renal, systemic disease in pregnancy except MTP

• Decrease appetite
• Cramping
• Sweating

• Injection Lutalyse 5ml,10ml (5mg/ml)
• Injection Pro Dino 5mg/ml

Prostaglandin F2α preparation

• Potent luteolytic agent
• It cause functional and morphological regression of the Corpus Luteum

• Drug of choice for endometritis in Cattle
• Anoestrus due to ovarian luteal cyst
• Silent / sub oestrus
• Termination of abnormal pregnancy (mummified foetus)
• Treatment of unwanted pregnancy
• Hydrops of foetal membranes
• Chronic endometritis / pyometra
• Induction of parturition
• Herd management
• Termination of pseudopregnancy
• Barren and maiden mares
• Synchronisation of oestrus

Cattle and Buffalo @

2ml (500mcg) - IM

Horses @

• Single IM Inj.  of 0.5-1 ml (mare have upto 400kg b.wt)
• 1-2 ml IM Inj (mare have more than 400kg b.wt)

Sheep and Goat @

0.5 ml (125 mcg) IM

Cat @

5 mcg/kg SC once daily for 3 days

Dog @

1-1.25 mcg/kg OD SC for 4-5 days 

• Pregnant animal (cause threatened abortion)
• Mare suffering from acute or subacute GI disorders and respiratory disease
• IV route is contraindicated

(Skin absorption is there, so take care during handling)

• Increased cardiac and respiratory rates
• Abdominal discomfort
• Watery diarrhoea
• Depression
• Vomiting and Nausea

(These signs are transient and last for 15-20 minutes)

Inj. PRAGMA (INTAS)

• 2 ml, 10 ml vials
• Each ml contain 250mcg

Inj. PREGOVA (VIRBAC)

• 2 ml vials
• Each ml contain 263 mcg 

inj pg estro (HESTER)

• 2ml vials
• 250mcg/ml

Inj. ESTRUMATE

• 20 ml vials
• Each ml contain 250mcg

Inj. CLOSTENOL

• 2 ml vials
• Each ml contain 250mcg

Inj. ALPHA TWO

• 2 ml vials
• Each ml contain 250mcg