Corticosteriods

Anti inflammatory, immunosuppressive, antiallergic

Treatment for Rhinitis, Asthma, Prophylaxis of nasal polyps

Recurrent airway obstruction in horse

Reduce bronchial secretion

500mcg/ animal BID

Horse @ 1-3mcg/kg BID for 10 days (inhalation / nasal route)

Hypersenstivity to drug

Central serous retinopathy

Beclate Aquanose spray (150mcg/Pugg)

Beclate nasal spray (50mcg/spray)

Corticosteroid

• Alters transcription of DNA
• Potent anti-inflammatory activity
• Anti-inflammatory potency is 7.5 times greater than prednisolone

• Ketosis
• Inflammation of respiratory tract & urogenital tract
• Local inflammatory conditions
• Arthritis,
• Surgical, anaphylactic, traumatic & haemorrhagic shock
• Pregnancy toxemia
• Aid in inducing parturition
• Acute mastitis
•  Used to prevent and treat anaphylaxis associated with a transfusion or chemotherapeutic agents.

Ruminant:

• 0.5-1mg/kg IV/IM
• Parturition= 20-30mg
• Anti inflammatory= 0.02-2mg/kg

Horse

• Anti inflammatory= 0.01-0.2mg/kg
• shock  = 0.5-2 mg

Cat = 0.125 - 0.5 mg IV / IM

Dog =  0.5-1 mg IV / IM 

• Pregnant animal
• Renal disease
• Diabetes mellitus
• Systemic fungal infections
• Animals with arrested tuberculosis
• Peptic ulcer
• Acute psychoses
• Corneal ulcer 
• Cushingoid syndrome.

• Cushingoid in nature with prolonged use
• Impaired wound healing and delayed recovery from infections
• The risk of developing hypokalaemia is increased if corticosteroids are administered concomitantly with amphotericin B or potassium-depleting diuretics (furosemide, thiazides).

• Injection Dexona-5ml (4mg/ml)
• Tab. Dexona-0.5mg
• inj dexa care vet (VET PLUS) - 10 ml vials (4mg dexamethasone phosphate/ml)

Corticosteroids

• Alters the transcription of DNA leading to alteration in cellular metabolism causing a potent anti inflammatory action
• Enhances carbohydrate and protein metabolism glucocorticoid activity

• Septicaemia
• Ketosis (Large animals)
• Induction of parturition (small & large animals)
• Pregnancy Toxemia (Small animals)
• Allergy
• Anaphylactic Shock
• Dystocia
• High Temperature
• Acute Inflammations
• Pruritis
• Dermatitis
• Tendinitis
• Opthamic inflammation
• Arthritis
• Hypersensitivity

• Cattle @ 0.04 mg/kg
• Horse @ 0.o2-0.1 mg/kg
• Cat @ 0.25-0.5 mg/kg
• Dog @ 0.25-0.5 mg/kg

Other conditions

Dog

Occular@ 1 drop in affected eye 5-6 hr interval

Otitic @ 4 drop in ear 12hrs interval

Skin - apply @ 8-12h interval

Antiinflammatory @ 0.04mg/Kg I/V or I/M q3 weeks upto 4 injections

@ 0.025mg/Kg PO 24 hrs interval

Cats

Occular@ 1 drop in affected eye 5-6 hr interval

Skin - apply @ 8-12h interval

Antiinflammatory @ 0.04mg/Kg I/V or I/M q3 weeks upto 4 injections

Horse

Antiinflammtory @0.02-0.1mg/Kg 24hr interval I/m  or P/o

Cattle @ 10-20mg IM or IV Total dose

for Ketosis o.o4 -0.05mg/Kg IM or IV

Calf, Sheep, Goat , Pig @ 2-5mg Total dose IM or  IV

Intraarticular/ Periarticular

Cattle @ 4- 10mg

Dog @ 0.25 - 5 mg

Cat @ 0.25- 2mg

Tuberclosis, Round worm infection, increased cholestrol, insufficiency of hypothaamus and pitutary gland

In Pregnant animals

patients with renal disease and diabetic myelitis, Cardiac insufficiency, deep corneal ulcerations, recent major surgery

Decrease sperm output and sperm volume in dogs

Oral drops Betnesol - 15 ml

Ampoule Betnesol - 1 ml (4mg/kg)

Betnesol-N Ear/eye drop - 5ml

Osurnia tab - only for dog

Otomax Ear drop (14ml, 34 ml)

Inj Betamethasone - 5m vial (6mg/kg)

Diprovate cream - 20 gm

Beta vet

Betasone

Betnovate-N,

Anti haemorrhagic drug

Etamsylate (diethylamine- 2, 5 dihydroxy benzensulphonate) is a haemostatic agent used in human and veterinary medicine to control spontaneously haemorrhage after post operative care 

250-500mg (4-6 hours) after the surgery P/O

• porphyria (blood disorder) 

• Hypersensitivity

Skin rash, Nausea, low BP

Hemsyl - Inj 250mg/2ml and Tab 250mg, 500mg

Botrostat - Tab 250mg

Dicynene - Tab 250mg and 500mg and Inj 2ml (125mg/ml

Ethaklot - 2ml (125mg/ml)

Ethasyl - 2ml (Inj 125mg/ml)

Non selective COX inhibitors

Inhibition of cyclo-oxygenase activity

Analgesia

Antipyrexia

Antithrombotic

Antiinflammatory

Dog and cat 25-40mg/kg PO 3 time daily for dog, once daily for cat 

Cardiac, Renal, Hepatic diseases and hypersensitivity 

Intestinal irritation

Anorexia

Nausea

DOTCHROME-DS

Sodium salicylate 200mg/ml

Coagulants

Transform fibrinogen into fibrin by gradually splitting off fibrinopeptide A, giving rise to der-A-fibrin monomers, which polymerize end to end to fibrin

Control bleeding in surgical, dental and gynaecological cases 

Dog and cats- 10mg/kg

Cattle- 10-15 mg/kg

Hypersensitive patients

Not use in venous or arterial thrombosis 

Injection Blood off 20ml

Tablet Blood off 500mg

Inj Botropase - 1ml

Sol Botroclot - 10 ml

Sol Botroclot forte - 10 ml

Cardiac glycoside 

• Increase intracellular Calcium ion
• Increase contractility of myometrium

• Arterial tachycardia
• CHF

Dog= 5-8mcg/kg

Digitalis toxicity in overdose

• Diarrhoea
• Dizziness
• Blurred vision
• Skin rashes

• Injection Digoxin 0.5mg/2ml
• Tab. Digox 0.25mg

Anticholinergic and pre anaesthetic

Competitive antagonist of acetylcholine at all muscarinic receptor site

Pre anaesthetic
Antispasmodic
Broncodilator
Cardiac stimulant
Antidote to anticholinesterase
Sinus bradycardia
Cardiac arrhythmia
Brady arrhythmia
Organophosphate poisoning
Carbamate poisoning
Opthalmic ointment

PRE ANAESTHETIC

Cat and dog @ 0.02-0.1 mg/kg IM/SC

Cattle and horse @ 0.02-0.06 mg/kg IM/SC

ANTI CHOLINESTERASE

Cat and dog @ 0.2-2 mg/kg (1/4 IV and 3/4 IM/SC then same or half dose at 3-4 hours interval IM/SC )

Cattle, Horse, Sheep and goats @ 0.2-0.5 mg/kg (1/4 IV and 3/4 IM/SC then same or half dose at 3-4 hours interval IM/SC )

For adjunctive treatment of BRADYCARDIA

Cat & dog @ 0.02-0.04 mg/kg IM/SC/IV
@ 0.04 mg/kg PO 3-4 times daily

For opthalmic use 

0.5-2% opthalmic solution
1 drop, 2-3 times daily until get pupillary dilatation

Glaucoma
CHF
Myocardial ischemia
Intestinal hypomotility
Tachycardia
Obstructive uropathy
Hepatic or renal disease
GI infection

Dry mouth
Dysphagia
Constipation
Increased thirst
mydriasis
Tachycardia
Tachypnoea restlessness urine retention

Inj Tropin 1ml
Inj Atrotas 1ml

Bronchodilators 

Inhibition of phosphodiesterase enzyme leading to accumulation of cAMP

Bronchodilators 

Cat - 4mg/kg BID

Induce excite and hypocalcemia

Induce excite and hypocalcemia

Deryphilline - Tab 100 mg and Inj 220mg/2ml

• Bronchodilators
• Beta agonist

• Selective action on beta-2 adrenergic receptors - stimulate receptors to relax bronchial smooth muscles
• Inhibit release of inflammatory mediators especially from mast cells
• Direct acting Sympathomimetic

• Relieve Bronchospasm
• Relieve Bronchoconstriction

DOG@100-300 mcg/kg BW TID

Cat@100 mcg/kg BW TID/QID

Horse@0.008 mg/kg PO two times daily

Cardiac disease and late pregnancy, abolish uterine contraction.

Tachycardia

Nervousness

CNS excitation

Muscle Tremors

Tab. ASTHALIN 2mg, 4mg

Syrup. ASTHALIN 100ml (2mg/5ml)

Tab. LEVOLIN 1mg, 2mg

Tab. SALBID 2mg, 4mg