Antibiotics

A bacteriostatic Macrolides antibiotic binds to 50s ribosomal subunit suppressing bacterial protein synthesis

Against mycoplasma

Dogs -10 to20 mg/kg PO q 12 hrs,

cattle - 18 mg/kg IM q 24 hrs,

Goat - 10 mg/kg (do not exceed more than 5 days) ,

Birds - upper respiratory tract infection 10 -40 mg/kg IM, BID Or TID ,

elephant - 12 mg/kg OD for 5 days ( Mycoplasama infection)       

POWDER FORM                        Dogs- 1/16 th of teaspoon 2-3 times daily for dogs less than 7 kg, (greater than 7 - 15kg ) - 1/8 th of teaspoon  2-3 times a dog for medium dogs 1/4 teaspoon 2-3 times a day for larger dogs( greater than 15 kg) 

Don not give to guinea pigs, hamster, rabbits

• Gastro intestinal upset         pain and inflammation at injection site                             decreased appetite, diarrhoea

Trox powder (VIRBAC) - 120g (50%w/w)

powder TYLO 62.5,100g       

inj. Tylan 200,250ml

Macrolytic antibiotic
prokaryotic drug

Bind to 50s sub unit of bacterial ribosome and prevent growth of bacteria by interfering with protein synthesis

Only in foal below 1 year not above Respiratory tract infection
Genital tract
Skin and soft tissue
Against intracellular organism

Cattle @
As prokinetic @ 1.1 to 8.8 mg/kg IV Single dose in leucocytes

Cat @ 5mg/kg PO Once daily

Dog @ 5-10(upto 40)mg/kg PO Once daily

Foals @ 10 mg/kg PO Once daily (initially) followed by alternate days

Hypersensitive patient
Liver disfunction
Horse above 1 year fetal digestive disturbance

G.I disturbance
Very rarely nervousness dermatological reactions

Inj Azee 500mg (Each ml of reconstituted injection contains 100 mg)

Suspension Azee 100mg/ml

Tab Azee 250mg, 500mg, 1000 mg

Powder Azithral P 100g, 1000g

Marcrolid antibiotics

Like other macrolid antibiotics bind with 50s ribosomal subunit and cessation of bacterial protein synthesis

Cat @ 10-15 g/kg PO

dog @ 10-40g/kg PO

cattle, sheep, goat,horse @ 2.2-4.4 g/kg bw PO

Allergies from other macrolids like Azithromicin

• do not combine with digoxin

Nausea, vomiting, diarrhoea, stomach pain, loss of appetite

Althrocin - Tab 250 and 500mg and Liq 60 ml (125g/5ml)

Anithrocin FS. - Powder 1g

Erycin - Tab 125 mg, 250 mg, 500mg

Antibiotic

It inhibit the bacterial proteins synthesis

Gram-positive cocci

Obligate anaerobe

Cat & dog @ 22mg/kg IM q12h hrs parenteral

11mg/kg slow IV

Rapid IV should be avoided

Rapid IV can result in collapse due to cardiac depression

Inj lincovet 5ml and 30ml (300mg/ml)

Antibiotics

Inhibit bacterial synthesis of dihydrofolic acid

Soft tissue infection

coccidia

Pneumonia

Urinary tract infection

Dog and cat 100mg/kg PO IM or 50mg/kg BID PO

Cattle 220mg/kg PO, IM following 110mg/kg OD PO IM

sensitive animals

Blood dyscrasias

Anaphylaxis

Stevens-Johnson Syndrome

Bilsulpha 100ml

Bol. Sulphadimidine

Bol. Pabadine 5g

Fluroqunolones Antibiotics.(Eye, ear Antibiotics).

Inhibits bacterial DNA gyrase enzyme. 

Bactericidal.

Staphylococcus spp,Pseudomonas aerugenosis,Bacterial conjunctivitis,Bacterial infection of eye,corneal ulcer, skin infection, pneumonia.

Dog-10 mg/kg

Horse-5.8mg/kg.

<6months of age

CNS toxicity, especially in animals with renal failure

Opthocare M eye drops - 5ml.

Moxiflox eye drops-5ml,

Bromiflox eye drops -5ml,

Moxiflox P eye drops-5 ml,

Ointment: Moxiflox 0.5 %.

Inj:Mofoi [100mg/kg]  25 ml, 100ml vial

Fluoroquinolones antibiotics

• Inhibits specific bacterial enzymes (bacterial topoisomerase IV and DNA gyrase) needed for the bacteria to replicate and repair its DNA.
• Synthetic broad spectrum antibiotic with antibacterial activity against a wide range of bacteria including pseudomonas, staphylococcus, haemophilus, Enterobacter and E. coli. 

• Superficial skin infections (pyodermas)
• Respiratory infections
• Haemorrhagic Septicemia
• Bovine Respiratory Disease
• Pneumonia and Bronchopneumonia
• Acute & Chronic Mastitis
• Urinary bladder, kidney, prostrate, skin infection.

Cat - 2 mg per KG (IV, SC,oral ).

Dog-2 mg per KG (IV, IM,SC)

• 9kg (20lb)                half 50mg tablet
• 18kg (40lb)              one 50mg tablet
• 36kg (80lb)              two 50mg tablets

Poultry - 2mg per kg(Oral).

Conditions

• Mastitis: Daily dosing @ 2mg/kg B.wt. (1ml/50kg B.wt.) for 3 to 5 days
  by IV/IM/SC route.
• Respiratory Disease: Single shot @8mg/Kg B.wt. (4m/50kg B.wt.)
  by IM route

• Allergic 
• Animal which has GIT problem.
• Kidney or liver disease or a central nervous system disorder
• Under one year age.
• Pregnancy -Fetotoxicity

• Fetotoxicity
•  Nausea, vomiting, loss of appetite, increased thirst, diarrhoea and lethargy. 
• Convulsions or seizures are a rare side effect in pets with CNS disorders.

Inj Marbomet 30 ml (100mg/ml) (INTAS)

Tab Marbomet - 50 mg

Marbomet tablets 50mg  once daily with or without food, preferably at the same time each day.

Antibiotics (2nd gen. flouroquinolone) 

• Bactericidal
• Interferes with action of DNA gyrase (Topoisomerase II)  which inhibits the replication of bacterial DNA

• Urinary, genital, gastrointestinal tract and soft tissue infections

Cat & dog @ 22mg/kg  12hrs    PO

Birds @ 10 mg/kg Po OD

• In young animal - Cartilage injury
• Animal prone to seizures

• Spontaneous tendon ruptures
• Hepatotoxicity
• Allergic neuropathy
• At high doses, cause nausea, vomiting, and diarrhea.
• Arthropathy in young animals

Tab. Norflox 100mg, 200mg, 400mg

Tab Normax 400 mg

Susp Bacigyl 30 ml (Each ml contains 20 mg)

• Fluoroquinolones

• Broad spectrum antibiotics

Bactericidal drug

Inhibition of Deoxyribonucleic acid gyrase this inhibit both DNA and RNA synthesis

For the treatment of bacterial infection of alimentary canal and respiratory tract, skin infection

acute and chronic mastitis, wooden tongue, brucellosis, pyometra, bq, hs, otitis

wound, secondary bacterial infection associated with virus, urogenital infection

fowl cholera, infectious coryza, crd, pasteurellosis

Dog=> 5-20 mg/kg of body weight

Sheep, cattle=> 2.5-5 mg/kg body weight

Goats, pig=> 10 mg/kg body weight

Poultry=> 10-12 mg/kg (orally) 

Contradicted in young ones 12 month in small breeds of dog and 18 months in large breed of dog

• cartilaginous growth

• Epilepsy

• Gestation and lactation

Nausea, vomition, loose stools, allergy Or hypersensitivity

Meriquin - Syr 100ml and 500 ml (VETOQUINOL)

Meriquin vet - Inj 100 ml (100mg/ml) (VETOQUINOL)

Meriquin vet - Tab 50mg and 150mg (VETOQUINOL)

Inj fortivir (VIRBAC) - 10ml, 30 ml 50ml and 100 ml vials (100mg/ml)

Inj flobac sa (INTAS) - 30 ml vials (100mg/ml)

inj enrox (ALEMBIC) - 30ml vials (100mg/ml)

Quintas - Inj 15, 50 , 100 and 1000ml (100g/ml)

Enrocin - Inj 15ml and 100 ml (100mg/ml) and Tab 150mg

Enrobest Inj 15ml and 100 ml

Enbact - Inj 20ml, 100ml

Enrotreat - Inj (15ml, 50ml, 100ml) and Solution (500 ml and 5000ml)