Antiprotozoal 

Exact mechanism not known

It is medication used to prevent and treat malaria in area where Malaria remains sensitive to chloroquine

Autoimmune disease

Discoid lupus erythematous in dogs

Dog- 5mg/kg orally, OD with tacrolimus ointment

Overdose- drowsiness, visual disturbance, CV collapse, convullsion, HYPOKALEMIA

High dosage causes drowsiness

IMULAST tablet 200mg

HCQS tablet 200mg

QDMRD tab 200mg

RHQ tab 200 mg

Antiprotozoal (carbanilide diamidines) 

• Not clear
• Combining with protozoal DNA causing DNA to unwind and denature & interferes with DNA synthesis

• Antiprotozoal spectrum: babesia, cytauxzoon, hepatozoon, anaplasma, Ehrlichia.       Babesia (canis, gibsoni, caballi) 
• Intracellular tick borne pathogens
• Babesiosis, anaplasmosis, Ehrlichiosis, cytauxzoon folis infection

In cats not used

Horse @ 2.4 mg/kg IM

Cattle & Buffalo @ 3-4mg/kg IM

Dog @ 6.6mg/kg IM SC Once (Repeat in 2-3weeks)

• Low therapeutic index
• Mild cholinergic signs
• Anaphylaxis
• Pain at injection site
• Hepatic and renal impairment

Inj. Imizet (INTAS)

• 5 ml and 10ml vials
• 120mg/ml

Anti protozoal

Enters RBCs and inhibit parasitic cell and digestive vacuoles by simple diffusion 

Malaria

Avian malaria - 5mg/kg 6, 18, 24 hrs

NA

Na

Lariago - Tab 250, 500mg 

Syrup - 60ml (160mg/10ml)

Inj 5ml (64.5mg/ml)

Lincosamide antibiotic 

Inhibit protein synthesis by reversible binding to 50s ribosomal subunit, blocking the transpeptidation

Pyoderma, Toxoplasmosis, Bone and joint infection

Cat & dog @ 5.5mg/kg BID 

For toxoplasmosis in cat & dog @ 25mg/kg OD in divided dose

Rabbit, chinchillas, hamsters

In hypersensitive animals

Clivet - Solution 20ml (25mg/ml), Inj 2ml and Tab 150mg and 300mg 

Goclin - Tab 150mg and 300mg

Bioclan - Syrup 25mg/ml

Dalacin C - Inj 300mg/2ml

Clindapet - Tab 150mg and 300mg

Dalcap - Capsules 150 mg

Dalcinex - Caps 150 mg and 300 mg

Anti protozoa, antibiotics, Nitroimidazole.

Not known

(Bacteria under anaerobic condition, binds to DNA - Cause death)

-Interfere with pyruvate ferrodoxin reductase.

-Interfere with enzyme in the bacteria's electron transfer system.

Giardiasis, Intestinal problems,diarrhoea caused by protozoan,

Treatment of other parasites(Trichomones,Balantidium coli)

Treatment of anaerobic infection in horse 

Management of hepatic encephalopathy. 

Dog - 15 to 25 mg /kg for protozoan infection. (25mg/kg).

Cat -8  to 10 mg /kg.

Food animal prohibited. 

Equine- 20 to 25 mg /kg (BID).

Elephant- 15 mg /kg rectally.

1st trimester of pregnancy. 

Toxic to king cobra.

Toxic to small birds.

Vomiting, CNS Toxicity, Hepatotoxicity,hematuria.

Drug Interaction:

Phenobarbital, phenitoin may enhance, metabolism of metronidazole,

Cimetidine may decrease the metabolism of metronidazole.

inj meterkem (ALKEM) - 100 ml (5mg/ml) 

Inj metrogyl -100 ml(0.5 mg /ml).

Tablets:

Metrogyl- 200mg , 400mg 

Flagyl - 200 mg ,400 mg .

Susp:

metrogyl - 30 ml, 60 ml(40mcg /ml).

Flagyl - 60ml (40mcg per ml).

Antibiotic

• Bacteriostatic
• Inhibit protein synthesis

Tickborne disease (DOC)

Dog:

• Anaplasmosis= 5-10mg/kg PO q 12hr 7-10 days
• Toxoplasma gondii= 5-10mg/kg for 4 weeks
• General infection= 3.5mg/kg PO q 12hrs 7-14 days

Ruminant= 20mg/kg

Hypersensitive patient

• Decrease appetite
• Difficulty in swallowing
• Feel discomfort

• Doxicip-100- 100 capsule
• WELLDOX-100   100mg
• Dr Doxy 300 mg
• Doxy Must Tab 300 mg
• Doxicip Tab 100mg and 200mg

Antibiotics

Inhibits bacterial protein synthesis

bacteriostatic, broad spectrum antibiotics, rickettsial , spirocheter mycoplasma and other microbes

• Cattle = normal dope = 5-10 mg/ kg IM OD 2.5-5mg/kg IV OD 
• Anaplasma 20mg/kg for control or prevention every 21-28 days IM
• For eliminating coma state 22mg/kg IM or IV for 5 days
• Theileria 20mg/kg IV or IM for 10 days 
• Sheep/Goat - 6-11 mg/kg IV or IM
• Horse 6.6-10 mg/kg slow IV
• Dog - 7.5-10 mg/kg IV, BD 10-20mg/kg PO , BD
• Cats - mycoplasma 10-25 mg / kg IV , TID for 5-7 days  .Heamobartonelcosis - 16-20mg/kg PO, TID
• Birds controlling outbreak -200mg/kg IM OD 3-5 days .   Psittacosis 50mg/kg IM OD, 3-5 days 

Hypersensitivity reford fetel skeletal development, Hepatotoxicity , teratogenic effect (2nd half of pregnancy)

• Rapid IV can cause cardiac arrhythmias and transient collapse due to chelation of intravascular ca2+ ions
• Oral tetracycline should not be given to the Cats cause fever, hair loss,colic vomiting, diarrhoea, hypotension

vetocyclin ds ( VETOQUINOL)

• Inj 30ml and 100 ml vials
• 100mg/ml

oxetetracycline hydrochloride injection ip vet ( VETOQUINOL)

• Inj 100 ml vials
• 50mg/ml

Avoxin

• Inj 100ml
• Each ml contains 50mg

Avoxin LA

• Inj 50 ml
• Each ml contains 200 mg

Oxyney 

• Inj 100ml
• Each ml contains 50mg

Bixy DS

• 30 ml, 100ml vial
• (100mg/ml)

Bioxy LA

• 30 ml
• Each ml contains 200 mg

V cycline

• Powder 30%
• 100g , 500g

 Terramycin

• Powder 30g
• Inj 20 ml, 200 ml, 500 ml
• Each ml contains 200 mg

Oxytetracyclin Tab. 500mg

• Steclin
• 30ml, 50ml, 100ml
• Each ml contains 50mg

Anti Protozoal

Block the parasite respiratory chain

Used for therapy and  Prophylaxis of all forms of theileriosis

Have antileshmanial activity

2.5 mg /Kg IM single dose

Strictlya as Deep IM injection

Inj Zubion (INTAS)

• 2ml, 20ml and 30ml vials
• 50mg/ml

Inj Zubion f (INTAS)

• 30ml vials
• Each ml contains 50mg buparvaquone + 55 mg furosemide 

Butalex 50mg/ml

Boviquone

Prozoff

vetbuparva

Anti protozoal 

It inhibits DNA synthesis by interfere with aerobic glycolysis 

Trypanosomiasis, babesiosis, Cytauxzoonosis

• Dog:-
• For Babesia= 3.5-5 mg/kg I/M (B. canis)

3.5-5mg/kg I/M 24 hrs (B. gibsoni)

• For Trypanosomiasis= 3.5-7 mg/kg I/M 2 weeks
• Ruminants = 3.5mg/kg I/M

Vomiting and diarrhoea in dogs

• Tachycardia
• Nystagmus
• Opisthotonos

Inj nilbery (INTAS)

• 30 ml and 90 ml vials
• Each ml contains 70mg diminazine aceturate + 375mg phenazone

Inj Prozomin (VIRBAC)

• 30ml, 100ml vials
• Each ml contains 70mg diminazine aceturate + 375mg phenazone

• Injection Berenil Vet 7% 20ml,30ml,90ml
• Injection Batrynil 30ml,90ml
• Inj Demin 100ml

Anti cancer ( Vinca alkaloid group)

• Inhibition of microtubule formation in mitotic spindle, resulting in an arrest of dividing cells at the metaphase stage
• For thrombocytopenia, increase thrombopoiesis, increase fragmentation of megakaryocytes, decrease platelet destruction and decrease destruction of platelets by macrophages

• Transmissible venereal tumor (TVT) in dogs
• Mammary neoplasia in cats
• Lymphoreticular tumors
• Rhabdomyosarcoma

(Use gloves while administering drug)

Dogs and Cats@

Antitumor

0.025-0.05 mg/kg IV (once/week)

Thrombocytopenia

0.02 mg/kg IV (once/week) with prednisolone

• Teratogenic and embryo toxicity in pregnant animal
• IV route only
• Fatal Intrathecally (if given, immediate removal of spinal fluids and flush with RL as well as other fluids)

• Neuropathy
• Constipation
• Irritating to tissue (Avoid extravasation outside the vein)

Inj Vinlon 1

• 1ml vial
• Each ml contains 1 mg

Inj Cytocristin

• 1ml vial
• Each ml contains 1 mg