Beta blockers (Anti-hypertensive)

Effective by reducing total peripheral resistance and vast dilation, by blocking alpha adreno receptor

Chronic heart failure

Dog

Initial dose - 0.1-0.2 mg/kg BID

Target dose 0.4mg/kg BID

Supraventricular bradycardia

Av block

Avute heart failure

Carca

Tab 3.125, 6.25 and 12.5 mg

Cevas

Tab 3.125 and 12.5 mg

Antihistamine

Responsible for a wide variety of allergic symptoms rich as puritis, rhinorrhea and watery eyes 

Hydroxyzine is a potent inverse agonist of histamine H1 receptor. They not only block the completely stop activity of lutamine receptors 

Inverse agonism increase the hydroxyzine deficiency

Antipruritic, Antihistamines

Flea allergy dermatitis

Dog- Antipruritic/flea allergy- 2.2mg/kg 

Cats- Antipruritic - 1-2mg/kg

Horse- 0.5- 1mg/kg BID

Birds- Allergies- 1 to 2 mg in 120 ml water /2mg/kg TID

Dry mouth, decrease GI secretion

Some teratogenic effects

Tablet Atarax 10mg, 25 mg

Atarax syrup 100ml (10mg/50ml) 

Atarax drop 15ml(6mg/ml) 

Injection Atarax 2ml (25mg/ml) 

Antihistamine

Seratonin antagonist, Calcium channel blocker

It bind and block the H1 histamine and serotonin receptors

Inappetance

Allergy

Cat and dog @ 0.1-0.5 mg/kg BID /TID

Use carefully in urinary retention and pyloroduodenal obstruction. 

Ciplactin

Tab 2 mg and 4mg, Syrup 100 ml (2mg/5ml)

Practin

Tab 4 mg and Syrup 100 ml (2mg/5ml)

Antihistamine, local anesthetic

Act by preventing the binding of histamine to HI receptor 

Antihistaminic, can be allergic , anaphylactic reactions

Dog/cat-0.2-0.4 mg/ kg I/M, 5.25-12 mg/kg PO

Mild sedation or reduced seizure threshold

Convulsions, high fever, muscle stiffness

Phenergan 

• 2 ml ampoule
• Each ml contains 25 mg

Avomine

• Tab 25 mg

Anti histamine 

Block H1 receptor

Allergic reaction 

Prurirtis

Cattle @ 30-50mg total dose

cats @ 2mg/cat q12h PO

dogs @ 4-8mg/dog q12h PO (0.5mg/kg maximum dose q12h)

Glaucoma 

ileus

cardiac arrhythmia 

Don’t use in glaucoma, cardiac arrhythmias and ileus

Inj Anistamin (INTAS)

• 100 ml vials
• (10mg/ml)

Cadistin - Tab 4mg and Inj 30ml , 100 vial (10mg/ml)

Chlorazin - Inj 100ml (10mg/ml)

Chloril - 30ml and 100ml (10mg/ml)

Anti histamine

Pheniramine acts as an antagonist to allergic symptoms stemming from inappropriate histamine release to reduce edema, itching, and redness

Itching of unknown genesis and of various localization, eczema, dermatitis, urticaria, skin oedema, insect bites, photodermatitis, rhinitis, tail eczema in horses, stomatitis, toxic hoof corns and inflammation of the hooves of cattle, paresis during pregnancy, puerperal toxemia and secondary retention, pulmonary oedema in cattle, pulmonary emphysema in horses, toxic hypopepsia.

IM / IV

Large animals: 5-10 ml or more

Small animals: ½ -1 ml or more

Injection may be repeated after 8-12 hours, if necessary.

Allergy 

Lethargy, vomiting and diarrhoea 

Inj Avilin Vet

• 10 ml, 33 ml vials
• Each ml contains 22.75 mg

Inj Alert Vet

• 10 ml, 30 ml vials
• Each ml contains 22.75 mg

Inj ALG Vet

• 30 ml, 100ml vials
• Each ml contains 22.75 mg 

Inj Hisloc

• 100 ml, 30 ml vials
• Each ml contains 22.75 mg

Inj Histal

• 10 ml, 30 ml vials
• Each ml contains 22.75 mg

Inj Pheniramine maleate

• 30 ml vials
• Each ml contains 22.75 mg

Antihelmintic drug

Affect Cl-channel of CNS of arthropod

• Endo and ectoparasiticide
• GI infection
• Lungworm
• Lice
• Mange

Cat = 0.6mg/kg S/C weekly once

Dog= 0.6mg/kg S/C weekly once for 4 week

Cattle= 0.2mg/kg S/C or I/M

Nil

• Oedema
• Pruritis 

• Doramcare 1%
• Duromect 1%
• Inj Dectomax 100 ml (10mg/ml)

Ectoparasiticides

Inhibit glutamate gated channel results

Flaccid paralysis of parasite

Flea and ear mite infestations

Dog @ 6mg/kg

Cat @ 6mg/kg

Not use under 6 week of age

Swelling and pruritus after administration due to hypersensitivity of dead parasites

Redicate spoton 0.5ml, 0.7ml, 1ml, 2ml, 3ml

Revolution

Anti helmintics drug

Uncoupling of oxidative phosphorylation in flukes and distrubs the production of ATP in flukes. 

Amphistomiasis, moneziasis, fascioliosis(fasciola hepatica) 

• Cattle/Buffalo- 10-15mg/kg  PO
• Sheep/goat- 15 mg/kg  PO

It's not used in cat and dog. 

Salivation, fever, cutaneous vasodilation, tachycardia, severe respiratory distress. 

Distodin 

• Bolus
• 1g, 200mg Oxyclozanide

 Clozan plus

• Tablet
• 1.5g ( Oxyclozanide+Levamisole) 

Zanil

• Susp. 100ml
• Each ml contains 34 mg

Neozide

• Solution 90 ml, 1 L (Oxyclonazide + Levamisole)

Neozide plus

• Bolus 1.5g (Oxyclonazide + Levamisole) 
• Solution 90 ml (Oxyclonazide + Levamisole) 

Oxyleva

• Liquid 90ml( oxyclonazide + levamisole) 

Hexanide

• Bolus 1g (Oxyclonazide)

Hexanide Plus

• Supension 90 ml, 1 L (Oxyclonazide + Levamisole)

Fasnil/Fasmin

• Bolus 1.5 g, 6 g (Oxyclonazide + Levamisole)

Amphicide

• 1.5 g (Oxyclonazide + Levamisole)

Anthelmintics

Affect cl(-) ion channel of the nervous system of arthropods and nematodes.

It increases the membrane permeability. It causes hyperpolarization and death.

Enhances the release of GABA at presynaptic neuron.

Heart worm, ancylostoma spp,Toxacara, Toxascaris,Tricheris,Demodex, strangles vulgaris,Ascarids,pinworm,Hairworms,Stomach worms,lungworms, mites,lice.

Cattle-0.2mg per kg.

Horse-0.4mg per kg.

Cat-1 mg/kg.

Dog

Heart worms-3 mcg per kg ( every 30days) PO

Mange - 0.2 to 0.25 mg/kg(3 to 6 weeks).

Demodicosis-0.2 to 0.4 mg/kg -PO.

Dog< 2 month age.

Inj moxidecton (INTAS)

• 10 ml vials
• each ml contains 10 mg moxidectin + 40 mg benzyl alcohol 

Proheart 12 (10mg/ ml) 10 ml vial.