Ectoparasiticides

Toxic effect on nervous system of parasites resulting its death

Insect repellants

Medication for scabies and lice

For Cats

Benzyl Benzoate lotion 25%

Ectoparasiticides

Agonist of parasite octapamine receptor 

Canine demodicosis

Trichodectus canis

prevention of flea and ticks

Once/week

Demodicosis - 0.05% sol (4ml in 1 L)

Sarcoptic ascariasis - 0.025% sol (2ml in 1 L)

Rabbit

Puupy (less then 3 months of age)

Cutaneous absorption is common that leads to hypoglycaemia. So, always wear gloves during application 

Liq virtraz (VIRBAC )- 6ml, 15ml, 50ml and 500 ml bottle ( 12.5%)

pour on solution poron plus (ALEMBIC) - 30 ml (1% w/v Amitraz + 1% w/v Cypermethrin + 5% w/v piperonyl butoxide)

RIDD (12.5%)

Diptraz 

Hormones (Oxytocin preparation)

• Binds to specific oxytocin receptor present in myometrium and mammary glands of animal.
• It stimulate Frequency and forces of uterine myometrial contraction. 
• Having uterotonic activity and supports ejection of milk
• Stimulates releasing of prostaglandins E2 by amnion cells, which play role in initiating of delivery
• Stimulates secretion of prostaglandins PGF2α by endometrial cells, which produce luteolysis in non-pregnant animal
• PGF2α influences the contractility of myometrium

• 1. To stimulate uterine contractions for facilitating parturition in animals
  2. To accelerate involution of uterus in post - partum animals
  3. To use as an adjunct therapy in Retained Fetal Membranes ( RFM )
  4. To control and stop post - partum hemorrhages
  5. To expel the pathological content of uterus in Endo metritis and Pyometra
  6. To promote milk letdown in case of Agalactia
  7. To remove residual milk and toxic material from the udder after parturition and during the treatment of infectious mastitis in animals .

BOVINE @

• Uterine inertia, uterine involution, Milk let-down, and mastitis @ 20-40 IU as IM / SC and 2.5-10 IU as IV route

EQUINE @

• Uterine Inertia @ 20-40 IU as IM / SC and 2.5-10 IU as IV route
• RFM @ 10-20 IU as IM / SC
• Milk Let-down and Uterus involution @ 40 IU as IM / SC and 10 IU as IV

OVINE & CAPRINE @

• Uterine inertia @ 10 IU as IM / SC and 0.5-2.5 IU as IV
• Milk let down and uterus involution @ 10-20 IU as IM / SC and 0.5-2.5 IU as IV

CANINE @

• Uterine inertia, uterine involution, Milk let-down, and RFM @ 2-20 IU as IM / SC and 0.5 IU as IV route

FELINE @

• Uterine inertia, uterine involution, Milk let-down, and RFM @ 2-20 IU as IM / SC and 0.5 IU as IV route

Rabbit @ 0.1-0.3 IU/kg  SC / IM

• Complicated deliveries ( too big foetus , foetus abnormal position , torsio ute
  ri etc. )
• Insufficient release of cervix in case of Pyometra
• Uterine muscle hypertension
• Inappropriate used, oxytocin can cause uterine rupture or pain from excessive cramping. 
• Abdominal fetal position
• Uterine prolapse
• Cervical cancer

• Hyper contractions
• Uterine spasms or rupture in case of overdose

Inj. Pitocin

• 0. 5 ml ampoule
• Each ml contains 10 IU

Inj. Oxytocin Bio

•  50 ml vial
• Each ml contains 5 IU

Inj. Oxytocin-S

• 25 ml vial
• Each ml contains 10 IU or
• Each ml contains 0.18 mg

Ergot alkaloids

Increase the uterine contraction by decreasing the relaxation periods of uterine muscles

Increase the hemostasis 

For treatment of postpartum hemorrhage and post abortion hemorrhage is patient with uterine atony 

Cow and mares :- 2-5 mg/ animal

Ewe, goat, sow :- 0.5 to 1 mg/animal

Bitch and queen :- 0 . 2-0.4 mg/10 kg body weight

• Convulsions and gangrene

• Cause brody cardia and confurion diarrhoea, dizziness, dyspnoea, drowsiness, fast and weak pulse, miosis, loss of coagulation, vomition etc 

Diuretic

Increase uretheral outflow resistance and has some vasoconstrictive effects

For treating inconsistent secondary to urinary spinchter incompetence, also useful in nasal congestion management

Dog / cat- 0.5 mg/ kg B. Wt Or 1-2 mg / kg P/O q 12 h Or 1-1.5 mg/ kg P/O B/D Or T/D

Rabbit-5-10 mg / kg B. Wt

NA

Vomiting, diarrhoea, anorexia

PROIN tab. ( chewable), propalin 30 mL ( 50 mg/ mL) ,Ambrol -GPC syrup

Osmotic diuretics 

Increase the osmotic pressure,that prevents water reabsorption at the tubules 

1. Acute oliguric renal failure.              

2.Reduce introcular and intracerebral pressure

3. Reduce edema or ascites 

Cattle ,sheep,goat,swine - 1-3mg/kg IV 

horse - 0.25-2 mg/kg IV 

Dog and cat - 1-2 mg/kg IV 

Should not mix with whole blood

 Should not use in case of intracranial hemorrhage , severe haemorrhage severe CHF pulmonary edema anuric renal failure

Thrombophlebitis,skin necrosis

20% mannitol injection= 100ml,250ml,350ml

Diuretics

Na+, K+, 2cl- contransport inhibitors at thick ascending loop - prevent reabsorption 

Pulmonary edema

Acute renal failure

Hyper kalemia

Hyper tension

Dogs- 2-4 mg/kg q1 1-6 hrs I/V I/M S/C 

cat- 0.5-2 mg/kg q 8 hrs

Not use along with aminoglycosisdes

Nephrotoxicity & ototoxity when used with aminiglycosides

Increase azotemia when used with NSAIDs and ACE

Injection  Ridema (VETOQUINOL) 10ml vials (50mg/ml)

Injection Lasix-4ml (10mg/ml)

Tablet Lasix- 40mg

liquid laxabulk (VET MANKIND) - 150 ml (each 5 ml contains 1.25 ml liq paraffin + 3.75 ml milk of magnesia + 3.33mg sodium picosulphate)

Amp Fruseure 2ml

Amp Rasix 2ml

Amp Facemed 2ml

Thiazide (Diuretic) 

Act mainly at distal tubule to decrease the resorption of Na+ by inhibition of the Na+Cl- co-tansporter in the luminal membrane

For congestion heart failure, when the clinical signs become refractory to frusemide

Dog- 12.5-25mg/dog

Care 12.5mg/cat 1-4mg/kg P/O

Renal impairment, tends to reduce glomerulan filtration rate

Reduce GFR

Oral 50mg, 25mg, 12.5mg tablets

ESIDREX, HYDRIDE, XENIA

Hydrazide tablet- 12. 5mg, 25mg

• Corticosteroids

vasoconstriction and suppression of membrane permeability, mitotic activity, immune response and release of inflammatory mediators.

• Bovine ketosis
• Arthritis
• Tenosynovitis
• Inflammatory conditions
• Allergy
• Pruritis
• Haematoma
• Dermatitis

Large animals @ 12-20 mg IM or SC

Small animals @ 0.1 - 0.2 mg/kg IM or SC

Special Conditions

Arthritis and Tenosynovitis @ 6-18 mg Intra-articular

Bovine Ketosis @ 2-5 mg to 10 mg Intra-mascular

Allergy

High dose - vomiting, diarrhoea.

Vetalog Injection - 

• 5 ml vial
• Each ml contains 6mg

Glucocorticoid

Bind to specific glucocorticoid receptors

• Mastitis (especially endotoxin induced mastitis)
• Shock
• Milk fever
• Anti inflammatory / immunosuppressive effect
• Adjunctive treatment of bovine ketosis
• Allevating pain, lameness associated with musculoskeletal conditions
• Severe toxicity, shock, stress conditions.

Dose in ml

Cattle and Buffaloes: 5-10ml according to size of the animal and
severity of the conditions.

Horse: 2.5-1Oml.

Small animals: 1ml per 50kg
b.wt. by IM or IA route only.

Dose in mg(Total)

Cattle: 10-20 mg Total dose IM OD/BID

Horse: 5-20 mg Total dose IM OD/BID

Dose in mg(Body wt.)

Cattle - 0.02 mg/kg

Horse - 0.02 mg/kg

• Systemic fungal infections, administration of IM in patients with idiopathic thrombocytopenia
• GI ulcer patients, diabetes mellitus
• Downer cow

• Signs of hyperadrenocorticism
• Hypokalemia
• Retard growth in young one
• GI ulcer, pancreatitis, Hepatopathy, renal dysfunction, osteoporosis, laminaitis (horse) 
• Pregnancy
• Hypersensitivity

• Inj. Inerol 10 ml, 30 ml vials(2mg/ml) (INTAS)
• Inj. Safticort 10ml vials (2mg/ml) (VIRBAC)
• inj vetcort (ALEMBIC) 10 ml vials (2mg/ml)
• inj cortalife (VET MANKIND) 10 ml vials (2mg/ml)
• Inj. Isoflud 5ml, 10ml vials (2mg/ml)