Antibiotic

Inhibits bacterial cell wall synthesis

Shipping fever, erysipelas, strangles

Cattle- 20, 000 IU/kg

Horse -20, 000-25, 000 IU/kg

Diarrhoea

Nausea, pain, vomiting

Antibiotic

Interfere with bacterial cell wall synthesis without affecting protein synthesis within the cells

Actinomycosis, Black leg, Tetanus, Arthritis, Mastitis, Tetanus and wound infection

Dogs and cats

40000 - 50000 units / kg IM repeat after 5 days

Cattle 

10000 - 60000 units /kg SC or IM repeat after 2 or 3 days

Horses

50000 units /Kg IM repeat after 2to 3 days

Swine

10000 - 40000 units/Kg IM every 3 days

Birds

100mg/Kg IM once daily

Penicillin hypersenstivity patients

Deep intramuscular administration only

Hypersenstivity, GI disturbances, Platelet dysfunction, Organ toxicity, Cation toxicity

Pencom 12 Inj 12 Lakh IU

Antibiotic

Interfere with bacterial cell wall synthesis

Cattle, sheep-shipping fever by Pasturella multocida 

Swine- Erysipelas

Horse- strangles 

Give 6000 IU per kg increase dose to 12,000 - 18,000 IU /kg for serious infection

Diarrhoea, methaemoglobenemia, anemia

Nausea, pain, vomiting

Antiviral drug

• It inhibits enzyme neuraminidase which helps in viral replication and passage of virus into new cell through the mucus membrane. 
• It reduces the entry of parvo virus into the mucosa of the intestine. 

Parvo virus infection in dogs. 

Equine influenza A in horse. 

• Dog  -   CPVE-2. 2mg/kg  PO, BD for 5days
• Horse- Equine influenza-2mg/kg PO, BD for 5 days

Hypersensitivity patients

Nausea and vomiting

Susp. Antiflu - 12 mg/ml

Cap Antiflu  - 75 mg

Antiviral Drugs

Inhibits viral replication ( viral DNA polymerase) depends on viral thymidine kinase for phosphorylation. 

Ocular Feline Herpes virus (FHV-1) 

Cats - q4 - 6h  small amount to affected eye (max -3 weeks) 

Ocular irritation

Hepatic dysfunction, Myelosuppression ,        CNS effects - convulsions,  coma, Fever, Phlebitis. 

Simplovir eye gel - 5g

Natclovir -  250 mg capsule

Virson gel -  5g

Natelovir -  500 mg tab

Gancigel eye ointment- 5 g

Clygan gel 1.5g

Anti viral drug - Purine analogue 

Synthetic guanosine nucleoside analogue substitute guanosine in DNA synthesis and inhibits viral replication

• Herpes viral infection

Birds @ 80 mg/kg PO 3 times daily

Horse @ 10 mg/kg Slow IV 2 times daily

Dogs and Cats @ 3mg/kg PO 5 times daily for 10 days and upto 10 mg/kg PO 5 times daily for next 10 days

10-20 mg/kg slow IV infusion 3 times daily

• Renal impairment
• Dehydration 
• Hypersensitive patient

Oral - GI disturbance

IV - Renal insufficiency in dehydrated state

Topical - Local irritation

Tab Herperax 400 mg

Tab Zovir 200 mg

Cream Acivir 5%

Gel Cyclovir 5 % 

Antitussive

• Non competitive NMDA receptor antagonist
• Nicotinic cholinergic receptor antagonist
• Raise threshold of cough centre

• Cough suppression
• Chronic bronchitis

• Dog/Cat= 1-2mg/kg PO or T/D
• Cattle= 5-15mg/kg

• Pneumonia
• Lung disorder

• Slowed breathing
• Blurred vision
• Drowsiness

Tab. DMR 20 - 20mg

Antitussives 

Opioid antitussionves, selective full agonist of Mu opioid receptor 

To treatment of moderate to severe pain, cough, dyspnea

0.25mg/kg P/O TID

Chronic dung disease, obstructive pulmonary disease, pregnancy, bowel obstruction, increased intracranial pressure

Increase intracranial pressure 

Hysingla, zohydra(tablets) 

Analgesics, Antitussives

Opoid analgesic

Agonish K opoid receptor

Partial agonist of mu Receptor

Pain, combination with metdetomidine for sedation

Antitussive for chronicnon productive cough

Visceral pain, Colic in horse

In cats, combination with medetomidine and Ketamine by IV route to induce anesthesia of short duration

Dose 

Pre anesthetic

Dog

0.2 -0.4mg/Kg IM, SC

0.05mg/kg IV

Cat

0.4mg/kg SC IM

0.1mg/kg IV

Horse 

0.01 -0.06 mg/Kg IV

0.013 - 0.024 mg/Kg hr infusion

For Analgesia

Dog

0.2 -0.3 mg/kg SC, IM, SC

1- 4 mg/Kg PO 4 times daily

Cat

0.2 -0.4 mg/Kg SC IM

0.1 mg/Kg IV

1.5 mg/kg  PO 6 times daily

Ruminant

0.05 -0.2 mg/Kg 

Pig

0.1 -0.3mg/kg

Dog & Cat

0.2 - 0.4mg/kg IV (loading dose) followed by 0.1 -0.2 mg/kg /hr IV infusion

Horse

0.02 - 0.04 mg/Kg IV repeated after 3 -4 

0.04 - 0.2 mg/Kg IM repeated after 3-4 hr

Antitussive dose

Dogs 0.2 - 0.5 mg/kg

Neurolept analgesia

Dog & Cat

0.2 -0.4mg/kg IM combination with medetomidine (0.01mg/kg)

Horse

Ataxia, CNS exitement, Lower respiratory diseases, Bradycardia, Vomiting, Pregnancy

Ataxia, CNS exitation

High doses - Nystagmus, Salivation, Seizure, Hyperthermia, decreased GI motility

Inj Butdol 1mg/ml

Inj butdol 2mg/ml

Anti-spasmodic

Block the effect of Ach and inhibit the involuntary detrusor muscle contraction of urinary bladder. 

Stops bladder spasms

Dog - 0.2mg/ kg  PO, BD   Or 1.25-5mg total dose/dog

Cat- 0.5-1mg total dose/cat PO, BD

Gastric dysmotility, urinary bladder obstruction urinary retention

Urinary retention, excessive salivation, sedation, carstipation

Tab. oxyspas-2. 5mg, 5mg

Tab. Cystran- 2.5mg , 5mg

Tab. Tropon XL 5-5mg